导师简介-吴欢

发布者:刘芳 发布时间:2019-09-18 浏览次数:

吴欢,男,中国药科大学药物分析学博士,硕士生导师。主要承担本科生《药物分析》、《药物色谱分析》、《体内药物分析》和研究生《蛋白质组学与代谢组学》等专业课程的教学工作。研究方向:中药药效物质与质量评价、中药代谢组学。主持国家级课题1项、省部级课题2项,参与国家级课题6项。发表论文18篇,其中SCI收录12篇。担任Pharmaceutics杂志特约同行评议专家。获得安徽省药学会优秀学术论文奖2项。

一、主持或参加科研项目

1 国家自然科学基金青年项目,81903765,靶标代谢组经时谱效关系探究芪玉三龙汤抑制非小细胞肺癌药效物质基础,2020/01-2022/1221万元,主持

2 安徽省高等学校自然科学基金重点项目,KJ2019A0478,整合非靶标和靶标代谢组研究芪玉三龙汤抑制非小细胞肺癌作用机理及药效物质,2019/01-2021/126万元,主持

3 国家自然科学基金面上项目,81874360,栀子苷双靶调控SphK1-S1P-S1PR1Ras-Erk1/2信号转导干预类风湿性关节炎滑膜微环境炎症反应,2019/01-2022/1257万元,参加

4 国家自然科学基金面上项目,81872976,基于中药配位化学理论探究复方肝豆汤通过驱铜途径治疗肝豆状核变性的药效物质基础,2019/01-2022/1257万元,参加

5 安徽省博士后研究人员科研活动资助项目,2017B193,基于UPLC-QTOF-MSE系统辨识策略研究华蟾素片中化学成分及其体内整体代谢轮廓,2017/08-2019/074万元,主持

6 安徽中医药大学自然科学研究重点项目,2017zrzd005,芪玉三龙汤对顺铂化疗Lewis肺癌小鼠“减毒”作用的代谢组学研究,2017/01-2018/123万元,主持

二、近五年代表性学术论文

(1) Xiang Zhan, Huan Wu*, Hong Wu, Rong Wang, Chuan Luo, Bo Gao, Zhiwu Chen, Qinglin Li*. Metabolites from Bufo gargarizans (Cantor, 1842): A review of traditional uses, pharmacological activity, toxicity and quality control [J]. Journal of Ethnopharmacology, 2019, doi.org/10.1016/j.jep.2019.112178.

(2) Jun Fu, Hong Wu*, Huan Wu*, Ran Deng, Feng Li, Chemical and metabolic analysis of Achyranthes bidentate saponins with intestinal microflora-mediated biotransformation by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry coupled with metabolism platform, Journal of Pharmaceutical and Biomedical Analysis, 2019, 170: 305-320.

(3) Li Xu, Yi Liu, Hongfei Wu, Huan Wu, Xiaochuang Liu, An Zhou*. Rapid identification of chemical profile in Gandou decoction by UPLC-Q-TOF-MSE coupled with novel informatics UNIFI platform, Journal of Pharmaceutical Analysis, 2019, https://doi.org/10.1016/j.jpha.2019.05.003.

(4) Meimei Cheng, Huan Wu, Hongfei Wu, Xiaochuang Liu, An Zhou*. Metabolic profiling of copper-laden Hepatolenticular degeneration model rats and the interventional effects of Gandou Decoction using UPLC-Q-TOF/MS, Journal of Pharmaceutical and Biomedical Analysis, 2019, 164: 187-195.

(5) Huan Wu, Yang Chen, Qinglin Li, Yating Gao, Xingxing Zhang, Jiabing Tong, Zhiqiang Zhang, Jian Hu, Danyang Wang, Shijie Zeng, Zegeng Li*, Intervention effect of Qi-Yu-San-Long Decoction on Lewis lung carcinoma in C57BL/6 mice: Insights from UPLC–QTOF/MS-based metabolic profiling, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2018, 1102-1103: 23-33.

(6) Huan Wu, Yang Chen, Zegeng Li*, Xianhua Liu, Untargeted metabolomics profiles delineate metabolic alterations in mouse plasma during lung carcinoma development using UPLC-QTOF/MS in MSE mode, Royal Society Open Science, 2018, 5: 181143.

(7) Yang Chen, Huan Wu, Xinheng Wang, Chenyang Wang, Lei Gan, Jie Zhu, Jiabing Tong, Zegeng Li*. Huaier Granule extract inhibit the proliferation and metastasis of lung cancer cells through down-regulation of MTDH, JAK2/STAT3 and MAPK signaling pathways, Biomedicine & Pharmacotherapy, 2018, 101: 311-321.

(8) Huan Wu*, Dan Wang, Jin Meng, Juanjuan Wang, Fang Feng*, A plasma untargeted metabolomic study of Chinese medicine Zhi-Zi-Da-Huang decoction intervention to alcohol-induced hepatic steatosis, Analytical Methods, 2017, 9(4): 586-592.

(9) Huan Wu, Fang Feng*, Untargeted metabolomic analysis using LC-TOF/MS and LC-MS/MS for revealing metabolic alterations linked to alcohol-induced hepatic steatosis in rat serum and plasma, Rsc Advances, 2016, 6(34): 28279-28288.

(10) Huan Wu, Xixi Li, Xuemei Yan, Li An, Kaiwen Luo, Mingjing Shao, Yue Jiang, Rui Xie, Fang Feng*, An untargeted metabolomics-driven approach based on LC-TOF/MS and LC-MS/MS for the screening of xenobiotics and metabolites of Zhi-Zi-Da-Huang decoction in rat plasma, Journal of Pharmaceutical and Biomedical Analysis, 2015, 115: 315-322.

三、联系方式

电话:0551-65169051

邮箱:wuhuancpu@ahtcm.edu.cn

QQ273387059