个人简介：

李庆林，男，1968年5月出生。博士，教授，安徽中医药大学博士生导师，澳门大学博士生合作导师。先后毕业于中国药科大学和安徽医科大学，曾在上海中医药大学中药研究所从事博士后研究工作，2002-2008年期间先后在美国阿肯色医科大学从事博士后研究工作和在美国爱荷华州立大学任职Research Fellow。目前担任安徽中医药大学科研中心暨实验动物中心主任，新安医学教育部重点实验室副主任，安徽省中药研究与开发重点实验室副主任，安徽省现代中药重点实验室副主任；兼任安徽省医药生物技术协会副会长，安徽省实验动物学会副理事长，安徽省毒理学会常务理事，安徽省药理学会常务理事。2008年回国后已主持了国家自然基金面上项目3项，国家重大新药创制项目、教育部人才引进项目等十余项国家及省部级科研项目，主持康美药业、华润三九等企业合作开发项目20余项。2011年获得“安徽省青年科技奖”,2014年获得“安徽省优秀教育工作者”和“安徽省优秀药学工作者”等荣誉称号。先后获得安徽省自然科学奖、中国中医药科技奖和安徽省中医药科技奖等奖励；培养毕业研究生三十余人，连续获得三届安徽省百名优秀研究生论文奖。担任多家学术刊物编委和20余家SCI期刊源杂志特约审稿人。近年来发表论文100余篇，其中SCI论文30余篇。其中两篇论文入选F5000中文最优秀论文及2013年中文百篇最优秀论文奖。

在研项目：

基于PTEN-PI3K/AKT信号通路调控细胞自噬研究新藤黄酸逆转乳腺癌耐药的作用机制（81673650），国家自然基金面上项目，2017.1-2020.12 主持

表儿茶素调控JNK信号通路干预ApoE-/-小鼠动脉粥样硬化（SKLTOF20160107），茶树生物学与资源利用国家重点实验室开发基金，2016.11-2019.10 主持

代表性成果：

1. Shuyu Yang, Guixin Chou*, Qinglin Li*.Cardioprotective role of azafrin in against myocardial injury in rats via activation of the Nrf2-ARE pathway[J].Phytomedicine,2018, doi:10.1016/j.phymed.2018.04.042

2. Shengyong Luo, Rui Li, Zhiyong Le, Qinglin Li*, Zhiwu Chen*.Anfibatide protects against rat cerebral ischemia/reperfusion injury via TLR4/JNK/caspase-3 pathway[J].European Journal of Pharmacology, 2017,807，127-137

3. Cao Yin, Li Qinglin* . The variation of the 5-hydroxytryptamine system between chronic unpredictable mild stress rats and chronic fatigue syndrome rats induced by forced treadmill running[J]. Neuroreport, 2017,28（11）: 630-637

4.Hui Cheng , Na Xu , Wenxia Zhao , Jingjing Su , Mengru Liang , Zhongwen Xie* , Xianli Wu* and Qinglin Li*. (-)-Epicatechin regulates blood lipids and attenuateshepatic steatosis in rats fed high-fat diet [J]. Molecular Nutrition & Food Research,2017,61（11）：1700303DOI: 10.1002/mnfr.201700303

5. Mei Wang ，Youyang Hu ， Yifei Fan ， Yan Guo ，Fanglin Chen， Shuo Chen ，

Qinglin Li* and Zhiwu Chen*.Involvement of Hydrogen Sulfide in Endothelium-Derived Relaxing Factor-Mediated Responses in Rat Cerebral Arteries[J].J Vasc Res, 2016;53:172–185

6. Wang Mei, Chen Dong, Cheng Hui, Li Bin, Yan Fenggen Su Jingjing, Peng Cheng, Sun Meiling,Hu Yawen, Wang Xiaoshan, Wang Guanghui, Chen Zhiwu*, Li Qinglin*. Gambogenic Acid Kills Lung Cancer Cells throughAberrant Autophagy. PLOS ONE , 2014,9(1):e83604

7. Jiang Genlin , Li Qinglin*.Gastrodin inhibits glutamate-induced apoptosis of PC12 cells via inhibition of CaMKII/ ASK-1/p38 MAPK/p53 signaling cascade .Cellular and Molecular Neurobiology， 2014，34(4):591-602

8. Guoqi Zhu, Xiu Wang, Xuncui Wang, Xiaoxiang Li, Qinglin Li*. Neuroprotective Effects of Puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's Disease Model in Mice. Phytother Research , 2014,28（2）：179-186

9.Su J, Cheng H, Zhang D, Wang M, Xie C, Hu Y, Chang HC, Li Q*. Synergistic effects of 5-fluorouracil and gambogenic acid on A549 cells: activation of cell death caused by apoptotic and necroptotic mechanisms via the ROS-mitochondria pathway. Biological and Pharmaceutical Bulletin, 2014;37(8):1259-68

10.Genling Jiang , Yuqin Hu, Lanlan Liu Jiali Cai, Cheng Peng, Qinglin Li* .Gastrodin protects against MPP+-induced oxidative stress by up regulates heme oxygenase-1 expression through p38 MAPK/Nrf2 pathway in human dopaminergic cells. Neurochemistry International，2014,75:79-88

11. Bin Wang , Xianhua Liu , An Zhou , Mei Meng and Qinglin Li*.Simultaneous analysis of coumarin derivatives in extracts of Radix Angelicae pubescentis (Duhuo) by HPLC-DAD-ESI-MSn technique.Anal. Methods, 2014, 6：7996–8002

12. Xiaohong Yu, Xiaoxiang Li. Genling Jiang, Xuncui Wang, Hebron C. Chang, Walter H. Hsu, Qinglin Li*. Isradipine prevents rotenone-induced intracellular calcium rise that accelerates senescence in human neuroblastoma SH-SY5Y cells. Neuroscience,2013, 246 (5):243-253

13. Zhu, G., Wang, X., Li, Q*,Involvement of activation of PI3K/Akt pathway in the protective effects of Puerarin against MPP+-induced p53-dependent apoptosis. Neurochemistry International，2012，60（4）：400-408

14. Fenggen Yan, Mei Wang，Hui Chen,Xiaoshan Wang, Lunzhu Xia, Qinglin Li * . Gambogenic acid induced apoptosis referred to Erk1/2 and p38 inhepatic cell line HepG2 .Environmental Toxicology and Pharmacology，2012， 33（2）:181-190

15. Hongbo Chen, Lanzhen Zhou, Lin Mei, Xiaojun Shi, Qinglin Li * and Laiqiang Huang. Gambogenic acid induces time- and dose-dependent G0/G1 arrest and apoptosis involving inactivation of Akt pathway in U251 glioblastoma cells. Journal of Natural Medicines ,2012，66（1）:62-69

16.Guoqi Zhu, Ying Chen, YuYing Huang, QingLin Li and Thomas Behnisch.MPTP-meditated hippocampal dopamine deprivation modulates synaptic transmission and activity-dependent synaptic plasticity ，Toxicology and applied pharmacology , 2011,254（3）：332-41

17. Xun-Cui Wang , Guo-Qi Zhu , Shu Yang , Xiu Wang , Hui Cheng , Fei Wang , Qing-Lin Li *. Protective effect of paeonol against glutamate-induced apoptosis and ERK activation in PC12 cells .planta medica ,2011,77（4）：1695-1701

18. Hui Chen, Jingjing Su, Jianya Peng，Mei Wang, Xuncui Wang, Xiaoshan Wang, Fenggen Yan, Qinglin Li*. Gambogenic acid Inhibits Proliferation of A549 Cells through Apoptosis-Inducing through up-regulation of the p38 MAPK cascade. Journal of Asian Natural Products Research , 2011，13（11）：993-1002

19. Fenggen Yan, Mei Wang，Hui Chen,Xiaoshan Wang, Lunzhu Xia, Qinglin Li^*. Gambogenic acid mediated apoptosis through the mitochondrial oxidative stress and inactivation of Akt signaling pathway in human nasopharyngeal carcinoma CNE-1 cells European Journal of Pharmacology, 2011，652: 23-32.

20.Guoqi Zhu ,Xuncui Wang , Yuefa Chen , Shu Yang , Hui Cheng , Ning Wang , Qinglin Li*. Puerarin protects dopaminergic neurons against 6-OHDA neurotoxicity via inhibiting apoptosis and up-regulating GDNF in a rat model of Parkinson's disease. Planta Medica,2010；76（16）:1820-6

21. Gang Lu ,Qi-Xin Zhou, Shuo Kang , Qing-Lin Li, Liang-Cai Zhao, Jia-Dong Hen, Jian-Feng Sun, Jun Cao,Yu-Jun Wang, Jie Chen, Xiao-Yan Chen, Da-Fang Zhong, Zhi-Qiang Chi, Lin Xu, and Jing-Gen Liu. Chronic Morphine Treatment Impaired Hippocampal Long-Term Potentiation and Spatial Memory via Accumulation of Extracellular Adenosine Acting on Adenosine A1 Receptors. The Journal of Neuroscience, 2010 , 30(14):5058 –5070

22. Li, QL*.,Cheng, H., Zhu guoqi.,Yang, L., Su, JJ., Wang, XS., Zhou, A., Huang, P., Peng, DY. Gambogenic acid inhibits the proliferation of tumor cells and regulates expression of cox-2 and cyclin D1 genes in human lung Carcinoma A549 cells. Biological & Pharmaceutical Bulletin. 2010 ,33(3):415-420

联系方式

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Email：qinglin_lee@hotmail.com