
一、个人简历
吴鸿飞,女,1982年8月出生,教授,博士,博士生导师,安徽中医药大学药学院中药药理系副主任,安徽省中医药科学院中药药效与安全性评价研究所副所长,安徽省高校杰出青年,安徽省高校优秀青年人才,安徽省教坛新秀,安徽省优秀青年研究生导师。
主要研究方向:心血管疾病的机制和中药药物靶点研究,围绕新安医学经典药对“瓜蒌-薤白”及安徽道地中药活性成分丹皮酚,开展抗动脉粥样硬化作用及机制的科学研究;研究工作的开展对于弘扬新安医学的传统和特色、认识发掘新安医学经典名方的科学价值具有重要意义。近年来主持国家自然科学基金3项,安徽省自然科学基金面上项目、安徽省高校自然科学基金重点项目等省部级课题8项,发表论文50余篇,获安徽省中医药科学技术二等奖1项。
高等学校《中药药理学》课程联盟副秘书长兼理事,中国药理学会中药与天然药物药理专业委员会第二届青年委员会常务委员;中国药理学会抗炎免疫药理专业委员会第二届青年委员会委员;中华中医药学会中药实验药理分会第五届委员会青年委员;安徽省药理学会抗炎免疫药理学专业委员会副主委;安徽省药理学会个体化精准用药专业委员会副主委;Pharmacological Research: Modern Chinese Medicine的编委;《中国实验方剂学杂志》《中国动脉硬化杂志》编委;《中国药理学通报》《中药药理与临床》青年编委;Traditional Medicine Research (SCI新刊)青年编委;TMR Pharmacology Research青年编委;Phytomedicine,J Pharmaceut Biomed等期刊审稿专家。
二、教学科研情况
近年主持部分科研项目情况
(1)2022年国家自然科学基金-面上项目,82274137,基于Rab7调控血管平滑肌源性泡沫细胞脂噬探讨瓜蒌薤白药对“从痰论治”动脉粥样硬化的作用机制;
(2)2019国家自然科学基金-面上项目,81873038,基于血管平滑肌细胞自噬探究瓜蒌-薤白药对抗动脉粥样硬化斑块形成的作用机制;
(3)2011国家自然科学基金-青年基金项目,81001703,纳米乳经胃肠道吸收转运机制的研究;
(4)2022年度安徽省自然科学基金-面上项目,2208085MH275,基于Rab7调控LDs经溶酶体途径降解探讨“瓜蒌-薤白”抗动脉粥样硬化VSMCs源性泡沫细胞形成的机制;
(5)2022年安徽省高校杰出青年科研项目,2022AH020041,新安名方经典药对“瓜蒌-薤白”调控淋巴引流“从痰论治”抗动脉粥样硬化的新机制;
(6)2021年度安徽省教育厅高校自然科学研究项目-重点项目,KJ2021A0592,调控脂噬抑制VSMCs源性泡沫化样变-“瓜蒌-薤白”抗动脉粥样硬化的新机制;
三、论著情况
近年部分代表性学术论文
(1)Youli Bao#, Li Zhu#, Yuting Wang, Jiahui Liu, Zijian Liu, Zhenglong Li, An Zhou*, Hongfei Wu*. Gualou-Xiebai herb pair and its active ingredients act against atherosclerosis by suppressing VSMC-derived foam cell formation via regulating P2RY12-mediated lipophagy[J]. Phytomedicine, 2024, 155341.
(2)Li Zhu#, Youli Bao#, Zijian Liu, Jiahui Liu, Zhenglong Li, Xin Sun, An Zhou*, Hongfei Wu*. Gualou-Xiebai herb pair ameliorate atherosclerosis in HFD-induced ApoE-/- mice and inhibit the ox-LDL-induced injury of HUVECs by regulating the Nrf2-ferroptosis[J]. Journal of Ethnopharmacology, 2024,117892.
(3)Jinjin Yan,#, Yulong Yang#, Yarong Liu, Xiaoyan Shi, Hongfei Wu*, Min Dai*. MicroRNA let-7g links foam cell formation and adipogenic differentiation: a key regulator of Paeonol treating atherosclerosis-osteoporosis[J]. Phytomedicine, 2024,155447.
(4)Cuicui Liu, Qiao Liu, Mengnan Nian, Hongfei Wu*. , Shijian Cao, Huan Wu, Ting Dong, Peng Wu, An Zhou*. Identification and quantitative analysis of the chemical constituents of Gandouling tablets using ultra-high-performance liquid chromatography with quadrupole time-of-flight mass spectrometry[J]. Journal of sepapation science,2023.2300060.
(5)Yuting Wang , Xin Sun, Jingwen Qiu, An Zhou*, Pengbo Xu , Yarong Liu, Hongfei Wu*. A UHPLC-Q-TOF/MS-based serum and urine metabolomics approach reveals the mechanism of Gualou-Xiebai herb pair intervention against atherosclerosis process in ApoE-/- mice[J].Journal of Chromatography B,2023.123567.
(6)Xun Sun, Xinyu Zhang, Hui Yan, Hongfei Wu*, Shijian Cao, Wenchen Zhao, Ting Dong, An Zhou*. Protective effect of curcumin on hepatolenticular degeneration through copper excretion and inhibition of ferroptosis[J]. Phytomedicine, 2023,113, 154539.
(7)鲍友利, 曹寅, 吴鸿飞*.“瓜蒌-薤白”药对诱导自噬抑制NLRP3炎症小体激活减轻RAW264.7巨噬细胞炎症反应[J].中国中药杂志,2023,48(10):2820-2828.
(8)张博, 梁玉宁, 鲍友利, 朱利, 孙鑫, 吴鸿飞*. 基于网络药理学和实验验证探究经典药对“瓜蒌-薤白”治疗痰瘀互结心血管疾病的作用机制[J/OL].药学学报,2023.
(9)李加会,徐鹏博,钟华,周安,吴鸿飞*,戴敏*.代谢组学结合网络药理学技术探究“瓜蒌-薤白”药对抗动脉粥样硬化的配伍机制[J].中国中药杂志,2022.47(22):6208-6216.
(10)Yarong Liu, HuaZhong, PengboXu, An Zhou*, Lidan Ding, Jingwen Qiu, Hongfei Wu*, Min Dai. Deciphering the combination mechanisms of Gualou-Xiebai herb pair against atherosclerosis by network pharmacology and HPLC-Q-TOF-MS technology[J]. Front Pharmacol.,2022, 13:941400.
(11)丁立丹,徐鹏博,鲍友利,黄佳静, 吴鸿飞*. 瓜蒌⁃薤白对ApoE-/-小鼠动脉粥样硬化过程中NLRP3炎症小体活化的影响[J].中国动脉硬化杂志,2022, 30(1):27-35.
(12)Fengxia Yin, Mengnan Nian, Na Wang, Hongfei Wu*, Huan Wu, Wencheng Zhao , Shijian Cao, Peng Wu, Zhou An*.Protective Mechanism of Gandou Decoction in a Copper-Laden Hepatolenticular Degeneration Model: In Vitro Pharmacology and Cell Metabolomics[J]. Front Pharmacol.,2022, 848897. doi: 10.3389/fphar.2022.848897.
(13)鲍友利,曹寅,吴鸿飞*. 脂噬在动脉粥样硬化中的作用及中医药干预研究进展[J]. 中国动脉硬化杂志,2022,30(9):753-763.
(14)徐鹏博,丁立丹,仇静文,钟华,吴欢,周安,吴鸿飞*,戴敏.基于肝脏代谢组学研究“瓜蒌-薤白对ApoE-/-小鼠动脉粥样硬化的影响[J].中国中药杂志,2021,46(20):5320-5329.
(15)Rujing Xu, Juan Liang, Meimei Cheng, Hongfei Wu, Huan Wu, Shijian Cao, Wenchen Zhao, Ruichao Xu, An Zhou*. Liver and urine metabolomics reveal the protective effect of Gandou decoction in copper-laden Hepatolenticular degeneration model rats. J Chromatogr B Analyt Technol Biomed Life Sci[J]. 2021,1179:122844.
(16)Na Wang, Meimei Cheng, Xueyan Zhang, Hongfei Wu*, Huan Wu, Shijian Cao, Peng Wu, An Zhou*. Gandou Decoction Decreases Copper Levels and Alleviates Hepatic Injury in Copper-Laden Hepatolenticular Degeneration Model Rats[J]. Front Pharmacol. 2020,11:582390.
(17)黄瀚文,刘雅蓉,施晓艳,何海,刘玲,吴鸿飞*,戴敏*.基于血管平滑肌自噬探讨瓜蒌-薤白对ApoE-/-小鼠动脉粥样硬化斑块形成的影响[J].中国实验方剂学杂志,2021,27(06):23-29.
(18)钟华,仇静文,吴鸿飞*,徐赫,张鹏,薛程姣,贾鹏程.基于网络药理学研究瓜蒌-薤白药对抗高脂血症作用机制[J].中国实验方剂学杂志,2020,26(18):154-165.
(19)Qian Xu, An Zhou, Hongfei Wu*, Yujie Bi. Development and in vivo evaluation of baicalin-loaded W/O nanoemulsion for lymphatic absorption. Pharm Dev Technol. 2019 ,24(9):1155-1163.
(20)Hui Yan, Zhuan-Di Zheng, Hong-Fei Wu*, Xiao-Chuang Liu, An Zhou*. A microemulsion high-performance liquid chromatography (MELC) method for the separation and determination of hydrolyzed tenuifolin in Radix Polygalae [J]. Sci Rep. 2019,13;9(1):19108.
(21)Hongfei Wu, Aiwei Song, Wenjun Hu, Min Dai*. The Anti-atherosclerotic Effect of Paeonol against Vascular Smooth Muscle Cell Proliferation by Up-regulation of Autophagy via the AMPK/mTOR Signaling Pathway[J]. Front Pharmacol. 2018,8:948.
(22)Lei Wu, Yujie Bi, Hongfei Wu*. Formulation optimization and the absorption mechanisms of nanoemulsion in improving baicalin oral exposure[J]. Drug Dev Ind Pharm. 2018,44(2):266-275.
(23) Sufei Chen#, Jing Zhang#, Lei Wu, Hongfei Wu*, Min Dai*. Paeonol nanoemulsion for enhanced oral bioavailability: optimization and mechanism[J]. Nanomedicine. 2018,13(3):269-282.
四、研究生带教情况
2012年开始指导硕士研究生,已毕业20余人,现正在指导硕士生9人。
五、联系方式
E-mail:wuhongfei2009@126.com