一、 个人简历
教育经历：
1990.9–1996.6, 中国药科大学, 药物分析, 博士
1984.9–1988.7, 第二军医大学, 药学, 学士
科研与学术工作经历：
2015.4-至今, 上海交通大学, 医学院-上海市第一人民医院, 主任药师、教授
2002.2-2015.4, 第二军医大学, 药学院, 教授
1997.2-1999.2, 南京大学, 博士后
二、 教学科研情况（包括主要在研课题、获奖成果等）
主持临床药学获2016年上海市卫计委重要薄弱学科和2019年上海市卫生健康委腾飞计划-展两翼重点学科。主持完成包括 “十一五”重大新药创制专项“综合性新药研究开发技术大平台—临床前药物代谢动力学技术平台”、“十二五”“军队特需药品药物分析与质量控制技术平台”建设和美国比尔及梅林达•盖茨基金、科技部“重大新药创制”专项、科技部863项目、科技部国际合作项目、国家自然科学基金项目以及中药现代化研究与创新药物代谢与动力学研究项目等50余项。
目前已主持完成新药研发包括药物制剂生物利用度评价、临床药代动力学研究、临床前药物代谢与动力学分析等80余项；获新药证书10余项：化学一类新药阿德福韦酯获得了国家新药证书，化学一类新药艾迪康唑乳剂、吡拉格雷钠注射液、注射用吗利福肽、注射用奥美克松钠、注射用头孢他美钠、赛拉瑞韦钾片和中药一类新药虎杖苷注射液、丹参素钠注射液取得了新药临床研究批文。研究成果获国家发明专利10余项。以第一作者或通讯作者在J Proteome Res、Toxicology、Anal Chim Acta、Anal Bioanal Chem、Talanta、J Chromatogr A、J Chromatogr B、J Pharm Biomed Anal等国际杂志发表SCI论文130余篇，主编、副主编药学教材及学术著作10余部，培养博士与硕士研究生60余名。
三、 论著情况（包括代表性论文、专著、教材）
近五年：
1. Wang, L., Y. Fei, H. Qu, H. Zhang, Y. Wang, Z. Wu and G. Fan (2024). "Five years of safety profile of bevacizumab: an analysis of real-world pharmacovigilance and randomized clinical trials." Journal of Pharmaceutical Health Care and Sciences 10(1): 1.
2. Huang, X., Wu, Z., Liu, Y., Jia, M., Zhao, W., Wang, S., Jiang, X., Lou, Y., and Fan, G. (2023a). Simultaneous determination of bicyclol and its two active metabolites concentration in rat plasma and application for pharmacokinetics study of bicyclol and optimized bicyclol-nanoparticles. Arabian Journal of Chemistry 16, 105287.（6.0/Q2）
3. Huang, X., Wu, Z., Qiaolongbatu, X., Qu, H., Ma, C., Xiang, Y., Jia, M., Liu, Y., Wang, S., Jing, L., et al. (2023b). Recycling preparative isolation of six bicyclol active metabolites from SD rat urine using macroporous resin, offline 2D LPLC/HPLC, and prep-HPLC combined with pharmacodynamic evaluation of two active metabolites. Arabian Journal of Chemistry 16, 105107.（6.0/Q2）
4. Huang, S., Z. Wu, B. Zhou, et al., Heat-Denatured Lysozyme is a Novel Potential Non-alcoholic Disinfectant Against Respiratory Virus. Food and Environmental Virology, 2023.（4.034/Q2）
5. Qu, H., J. Wu, C. Ma, et al., Safety Profile of Eltrombopag in Different Age Groups: An Analysis of Real-World Pharmacovigilance and Randomized Clinical Trials. Clin Pharmacol Ther, 2023.（6.903/Q1）
6. Zhao, Y., C. Ma, Q. Qiu, et al., Exploring the components and mechanisms of Shen-qi-wang-mo granule in the treatment of retinal vein occlusion by UPLC-Triple TOF MS/MS and network pharmacology. Sci Rep, 2023. 13(1): p. 5330. (4.996/Q2)
7. Qiaolongbatu, X., W. Zhao, X. Huang, et al., The Therapeutic Mechanism of Schisandrol A and Its Metabolites on Pulmonary Fibrosis Based on Plasma Metabonomics and Network Analysis. Drug Des Devel Ther, 2023. 17: p. 477-496. (4.319/Q2)
8. Liu, Y., M. Jia, A. Gao, et al., Attenuation of Liver Injury via Bicyclol–Bovine Serum Albumin Nanopreparation using a Green Synthetic Approach. Journal of Nanomaterials, 2022. 2022: p. 7740768.（3.791 /Q3）
9. Jia, M., Z. Wu, W. Shi, et al., Simultaneous online SPE-HPLC-MS/MS quantification of gefitinib, osimertinib and icotinib in dried plasma spots: Application to therapeutic drug monitoring in patients with non-small cell lung cancer. Journal of Pharmaceutical and Biomedical Analysis, 2023: p. 115275.(3.571/Q2)
10. Shi, W., Z. Wu, J. Wu, et al., A comprehensive quality control evaluation for standard decoction of Smilax glabra Roxb based on HPLC-MS-UV/CAD methods combined with chemometrics analysis and network pharmacology. Food Chem, 2023. 410: p. 135371.(9.231/Q1)
11. Huang, X., M. Jia, Y. Liu, Z. Wu*, Y. Lou*, G. Fan*,, Identification of bicyclol metabolites in rat plasma, urine and feces by UPLC-Q-TOF-MS/MS and evaluation of the efficacy and safety of these metabolites based on network pharmacology and molecular docking combined with toxicity prediction. J Pharm Biomed Anal, 2022. 220: p. 114947.(3.571/Q2)
12. Ma, C., Z. Wu, X. Wang, et al., A systematic comparison of anti-angiogenesis efficacy and cardiotoxicity of receptor tyrosine kinase inhibitors in zebrafish model. Toxicol Appl Pharmacol, 2022. 450: p. 116162.(4.460/Q2)
13. Wu, Z., M. Jia, W. Zhao, et al., Schisandrol A, the main active ingredient of Schisandrae Chinensis Fructus, inhibits pulmonary fibrosis through suppression of the TGF-beta signaling pathway as revealed by UPLC-Q-TOF/MS, network pharmacology and experimental verification. J Ethnopharmacol, 2022. 289: p. 115031.(5.195/Q1)
14. Hu, S., S. Wang, C. Qi, et al., Cost-Utility Analysis of Once-Weekly Semaglutide, Dulaglutide, and Exenatide for Type 2 Diabetes Patients Receiving Metformin-Based Background Therapy in China. Front Pharmacol, 2022. 13: p. 831364.(5.988/Q1)
15. Xu, L., X. Cheng, G. Zhu, et al., Therapeutic drug monitoring of amikacin: quantification in plasma by liquid chromatography-tandem mass spectrometry and work experience of clinical pharmacists. Eur J Hosp Pharm, 2022. 29(e1): p. e77-e82.(2.537/Q3)
16. Shen, X., G. Fan, G. Liu, et al., Severe adverse cutaneous reactions induced by gefitinib combined with antihypertensive and antihyperlipidemic drugs in lung cancer: a case report. Anticancer Drugs, 2022. 33(1): p. e802-e807.(2.389/Q4)
17. Tang, Y., C. Shi, Y. Qin, et al., Network Pharmacology-Based Investigation and Experimental Exploration of the Antiapoptotic Mechanism of Colchicine on Myocardial Ischemia Reperfusion Injury. Front Pharmacol, 2021. 12: p. 804030.(5.988/Q1)
18. Gao, F.Y., H.Y. Chen, Y.S. Luo, et al., "Q-markers targeted screening" strategy for comprehensive qualitative and quantitative analysis in fingerprints of Angelica dahurica with chemometric methods. Food Chem X, 2021. 12: p. 100162.(6.443/Q1)
19. Fei, Y., S. Wu, Y. Wang, et al., A fast and high-sensitivity liquid chromatography-tandem mass spectrometry method combined with in vivo microdialysis for quantification of meropenem in rabbits with sepsis under the simultaneous infusion of total parenteral nutrition: Application to a pharmacokinetic study. Biomed Chromatogr, 2021. 35(7): p. e5100.(1.911/Q4)
20. Zhou, L., S. Wang, M. Chen, et al., Simultaneous and rapid determination of 12 tyrosine kinase inhibitors by LC-MS/MS in human plasma: Application to therapeutic drug monitoring in patients with non-small cell lung cancer. J Chromatogr B Analyt Technol Biomed Life Sci, 2021. 1175: p. 122752.(3.318/Q2)
21. Fei, Y., Y. Wang, S. Wu, et al., Evaluation of the efficacy and safety of a new formulation-lipid emulsion-based PTX injection: Pharmacokinetics, tissue distributions and anticancer effect on human gastric cancer cells in vitro. Biomed Chromatogr, 2021. 35(8): p. e5107.(1.911/Q4)
22. Xianyu Fan , Ji Li, Shengyuan Wu,Jingjing Jiang, Jiajing Wang, Shuowen Wang, Yuefen Lou, Guorong Fan. Field-amplified sample injection in capillary zone electrophoresis for the pharmacokinetic research of trace risperidone and its major metabolite 9-hydroxyrisperidone in beagle dogs. J Sep Sci 2020; 43:3555–3564. (3.614/Q2)
23. Shengyuan Wu, Xianyu Fan, Jingjing Jiang, Chih-Ming Ho, Xianting Ding, Yuefen Lou, Guorong Fan. Validation of a universal and highly sensitive two-dimensional liquid chromatography–tandem mass spectrometry methodology for the quantification of pyrazinamide, ethambutol, protionamide, and clofazimine in different biological matrices. Journal of Chromatography B, 1151 (2020): 122-141. (3.318/Q2)
24. Li-Ai Lan, Sheng-Yuan Wu, Xiang-Guo Meng, Jing-Jing Jiang, Ming-Yue Zheng,Guo-Rong Fan. A simple liquid chromatography tandem mass spectrometric method for fast detection of hydrogen sulfide based on thiolysis of 7-nitro-2,1, 3-benzoxadiazole ether. Journal of Chromatography A, 1625 (2020):1-12. (4.601/Q1)
25. Xiangguo Meng, Jingjing Jiang, Hui Pan, Shengyuan Wu, Shuowen Wang, Yuefen Lou and Guorong Fan. Preclinical Absorption, Distribution, Metabolism, and Excretion of Sodium Danshensu, One of the Main Water-Soluble Ingredients in Salvia miltiorrhiza, in Rats. Frontiers in Pharmacology, 2019, 10:1-10. (5.988/Q1)
26. Liai Lan, Shengyuan Wu, Yu Shidan, Jingjing Jiang, Honghong Chen, Yuefen Lou , Guorong Fan. Fast and direct determination of catechol-3, 6-bis(methyleiminodiacetic acid) prototype in beagle dog plasma using liquid chromatography tandem mass spectrometry: A simplified and high throughput in-vivo method for the metal chelator. Journal of Chromatography A, 1596 (2019):84-95. (4.601/Q1)
27. Shengyuan Wu, Liai Lan, Jingjing Jiang, Xianting Ding, Chih-Ming Ho, Yuefen Lou, Guorong Fan. Simultaneous determination of the potent anti-tuberculosis regimen-Pyrazinamide, ethambutol, protionamide, clofazimine in beagle dog plasma using LC–MS/MS method coupled with 96-well Format plate. Journal of Pharmaceutical and Biomedical Analysis, 168 (2019) 44–54. (3.571/Q2)
四、 主要研究方向，研究生带教情况
1.个体化治疗药物转化应用
2.药物代谢组学与临床分析
3.中药治疗化学生物学研究
五、 联系方式：
办公电话：34200090转3595
邮箱 guorfan@163.con
