一、个人简介
夏红梅，教授, 南京大学生命科学院生物学博士。长期从事细胞生物学、分子药理学、生物药物分析、功能性食品等相关的教学和科研工作。任合肥市药学会中药专业委员会常务委员。
主要研究包括肿瘤、炎症、心血管等疾病的发病和干预机制；中药材中次生代谢产物的基因调控机制；载运药物、中药有效成分、蛋白质、基因(siRNA，DNA等)的脂质体和外泌体及经修饰的脂质体和外泌体（CD44、ICAM-1等抗体修饰）、脂质体凝胶、脂质体和外泌体融合体等各种新型药物载体的组织和器官靶向治疗，特别注重于脑靶向、皮肤靶向、肝靶向等靶向药物的筛选及其跨血脑屏障、皮肤屏障、细胞膜屏障等载药系统的不断摸索和完善。
二、主持或参加科研项目
（1） 脑靶向穿膜肽RVG修饰脂质体和外泌体的融合体载川芎嗪透血脑屏障抑制缺血性中风，No:2023AH050754，安徽高校自然科学研究重点项目,安徽省教育厅，主持。
（2）抗ICAM-1抗体修饰的川芎嗪脂质体触发粘附反应透血脑屏障抑制缺血性中风NF-κB/HIF-1α通路，安徽省教育厅，重点项目，主持。
（3）CD44抗体修饰的多西紫杉醇纳米脂质体主动靶向抑制乳腺癌干细胞的分子机制研究，安徽省自然基金面上项目，主持。
（4） 治疗中风的黄芎抗栓胶囊深度开发研究，康缘中医药科技创新基金，主持。
（5）丹皮酚皮肤靶向纳米脂质体凝胶的制备和抑制黑色素合成作用的研究,安徽中医学院自然科学基金重点项目，主持。
（6）槲皮素抗氧化生物活性研究，企业委托研发类课题，主持。
（7）高效调控紫草药用天然产物合成相关miRNA的发掘及其分子机制研究,国家自然科学基金，面上项目，参加。
（8）川芎嗪油基纳米口服剂透血脑屏障机制研究,安徽省科技厅重点项目，参加。
（9）多西紫杉醇脂质体通过核转录因子Nanog 对乳腺癌干细胞的抑制作用，安徽省科技厅重大项目，参加。
（10）IL-12纳米脂质体制备和抗肿瘤作用的研究，安徽高校自然科学研究重点项目,安徽省教育厅，参加。
三、代表性学术论文和发明专利
1. 代表性学术论文
[1] Yu Wang, Yifang Wu, Si Shen, Yinyin Liu, Ying Xia, Hongmei Xia, * Zili Xie, and Yinxiang Xu. Engineered plant extracellular vesicles as natural delivery across physiological barriers. Food & function, 2024,15,1737-1757. (SCI, IF 6.1,中科院一区)
[2] Ying Xia, Keang Cao, Ruoyang Jia, Xue Chen, Yang Wu, Yu Wang, Zhiqing Cheng, Hongmei Xia *, Yinxiang Xu, Zili Xie. Tetramethylpyrazine-loaded liposomes surrounded by hydrogel based on sodium alginate and chitosan as a multifunctional drug delivery System for treatment of atopic dermatitis. European Journal of Pharmaceutical Sciences 193(2024)106680. (SCI, IF 4.6)
[3] Yan Yue, Yuqing Fang, Ruoyang Jia, Keang Cao, Xue Chen, Hongmei Xia * and Zhiqing Cheng. Study on the Antioxidant Effect of Shikonin-Loaded-Cyclodextrin Forming Host–Guest Complexes That Prevent Skin from Photoaging. Int. J. Mol. Sci. 2023, 24, 15177. https://doi.org/10.3390/ijms242015177 (SCI, IF 5.4)
[4] Yifang Wu , Mengmeng Wang, Yufan Li, Hongmei Xia *, Yongfeng Cheng, Chang Liu, Ying Xia, Yu Wang, Yan Yue, Xiaoman Cheng and Zili Xie. The Fabrication of Docetaxel-Containing Emulsion for Drug Release Kinetics and Lipid Peroxidation. Pharmaceutics 2022, 14, doi:10.3390/pharmaceutics14101993. (SCI, IF 6.525)
[5] Qin Zhang, Xinying Yang, YifangWu, Chang Liu, Hongmei Xia*, Xiaoman Cheng, Yongfeng Cheng, Ying Xia and Yu Wang. In Vitro Evaluation of Kaempferol-Loaded Hydrogel as pH-Sensitive Drug Delivery Systems. Polymers (Basel) 2022, 14, doi:10.3390/polym14153205. (SCI, IF 5.0)
[6] Chang Liu, Ying Xia, Yufan Li, Yongfeng Cheng, Hongmei Xia*, YuWang, Yan Yue, YifangWu, Xiaoman Cheng, Yinxiang Xu and Zili Xie. Ligustrazine as an Extract from Medicinal and Edible Plant Chuanxiong Encapsulated in Liposome–Hydrogel Exerting Antioxidant Effect on Preventing Skin Photoaging. Polymers 2022, 14(21), 4778; https://doi.org/10.3390/polym14214778 (SCI, IF 5.0)
[7] Yinyin Liu, Si Shen, Yifang Wu, Mengmeng Wang, Yongfeng Cheng, Hongmei Xia*, Ruoyang Jia, Chang Liu, Yu Wang, Ying Xia, Xiaoman Cheng, Yan Yue and Zili Xie. Percutaneous Electroosmosis of Berberine-Loaded Ca2+ Crosslinked Gelatin/Alginate Mixed Hydrogel. Polymers 2022, 14, 5101. https://doi.org/10.3390/polym14235101(SCI, IF 5.0)
[8] Chang Liu , Xiaoman Cheng, YifangWu, Weifang Xu , Hongmei Xia* , Ruoyang Jia, Yinyin Liu, Si Shen, Yinxiang Xu and Zhiqing Cheng. Antioxidant Activity of Quercetin-Containing Liposomes-in-Gel and Its Effect on Prevention and Treatment of Cutaneous Eczema. Pharmaceuticals 2023, 16, 1184. https://doi.org/10.3390/ph16081184(SCI, IF 4.6)
[9] Xinying Yang, Hongmei Xia *, Chang Liu, Yifang Wu, Xinyi Liu, Yongfeng Cheng, Yu Wang, Ying Xia, Yan Yue, Xiaoman Cheng, Ruoyang Jia. The novel delivery-exosome application for diagnosis and treatment of rheumatoid arthritis. Pathology - Research and Practice 242 (2023) 154332. (SCI, IF 3.309)
[10] Hongmei Xia*, Zhiqing Cheng, Yongfeng Cheng, Yinxiang Xu. Investigating the passage of tetramethylpyrazine-loaded liposomes across blood-brain barrier models in vitro and ex vivo. Materials Science and Engineering C: Materials for Biological Applications. 2016，69 (12):1010-1017. (SCI, IF 5.080)
[11] Yu Wang , Yan Yue , Ruoyang Jia, Xinyi Liu, Zhiqing Cheng, Yinxiang Xu, Zili Xie, Yongfeng Cheng and Hongmei Xia*. Design and Evaluation of Paeonol-Loaded Liposomes in Thermoreversible Gels for Atopic Dermatitis. Gels 2023, 9, 198. https://doi.org/10.3390/gels9030198. (SCI, IF 4.432)
[12] Zhi Li, Jing Li, Guokai Wang, Yaotian Tao, Xiangwei Chang, Hongmei Xia* and
Shuangying Gui. Reviewing Propolis with Multi-components in the Treatment of Oral
Diseases through Multi-pathways and Multi-targets. Mini-Reviews in Medicinal Chemistry. 2021,21. (SCI，IF 3.737)
[13] Hongmei Xia*, Hongliu Jin, Yongfeng Cheng, Zhiqing Cheng, Yinxiang Xu. The Controlled Release and Anti-Inflammatory Activity of a Tetramethylpyrazine-Loaded Thermosensitive Poloxamer Hydrogel. Pharmaceutical Research. 2019,36(4)52 https://doi.org/10.1007/s11095-019-2580-0. (SCI, IF 3.335)
[14] Hongmei Xia*，Yinxiang Xu，Zhiqing Cheng，Yongfeng Cheng. Tetramethylpyrazine-loaded hydrogels: Preparation, penetration through the subcutaneous-mucous-membrane model, and a molecular dynamics simulation，AAPS PharmSciTech, 2017，18（5）：1720-1727. (SCI，IF 2.666)
[15] Hongmei XIA, Chengyi TANG, Heng GUI, Xiaoming WANG, Jinliang QI, Xiuqiang WANG and Yonghua YANG*. Preparation, cellular uptake and angiogenic suppression of shikonin-containing liposomes in vitro and in vivo. Bioscience Reports. 2013，33(2): 207-215. (SCI，IF 2.899)
[16] Qinqin Liu, Hongmei Xia*, Yinxiang Xu, Yongfeng Cheng, Zhiqing Cheng. Investigation on the Preparation, Characteristics, and Controlled Release Model of Paeonol-Loaded Liposome in Carbomer Hydrogel. Current Drug Delivery. 2020, 17(2):159-173. (SCI，IF 3.758)
[17] Xinying Yang, Hongmei Xia*, Yufan Li, Yongfeng Cheng, Yu Wang, Ying Xia, Yan Yue, Xiaoman Cheng and Zhaoxing Chu. In vitro and Ex vivo Antioxidant Activity and Sustained Release Properties of Sinomenine-Loaded Liposomes-in-Hydrogel Biomaterials Simulating Cells-in-Extracellular Matrix. Natural Product Communications.2022. 17(11): 1–11. (SCI)
[18] Mengmeng Wang, Hongmei Xia*, Xinying Yang, Qin Zhang, Yufan Li, Yu Wang, Ying Xia, Zili Xie. Berberine Hydrochloride-loaded Liposomes Gel: Preparation, Characterization and Antioxidant Activity. Indian Journal of Pharmaceutical Education and Research. 2023; 57(1):74-82. (SCI)
[19] Yufan Li, Yongfeng Cheng, Hongmei Xia*, Qin Zhang, Yan Yue, Ying Xia, Zhiqing Cheng, Yinxiang Xu and Zili Xie. Study on the controlled release and synergistic anti-oxidant activity in vitro and ex vivo of ligustrazine hydrochloride encapsulated into liposomes. doi.org/10.36721/PJPS.2022.35.6.REG.1503-1512.1 (SCI)
[20] Hongmei Xia*, Yongfeng Cheng, Yinxiang Xu, Zhiqing Cheng. Retinoic acid liposome-hydrogel: preparation, penetration through the mouse skin and induction of F9 mouse teratocarcinoma stem cells differentiation. BJPS. 2015，51 (8): 541-550. (SCI)
[21] Xiaoyu LIU, Hongmei XIA * & Yongfeng CHENG. Dual Drugs-loaded Liposome-in-gel: Preparation,Characterization, and Transdermal Delivery by Simulation of Diffusing In Vitro, Ex Vivo, and In Vivo. Lat. Am. J. Pharm. 40 (1): 57-67 (2021) (SCI)
[22] Hongmei XIA*, Zhiqing CHENG &Yinxiang XU. Paeonol Liposome-Hydrogel: Preparation, Penetration Through the Mouse Skin and Down-Regulation of the Expression of Tyrosinase. Lat. Am. J. Pharm. 2014，33 (8): 1267-72. (SCI)
2.发明专利
（1）一种测定脂质体包封率的方法.夏红梅，刘琴琴，胡青，王柯入，田林林，谢亚蓝，崔美佳，张哲，张晓辉. 公开号：CN108414393A
（2）用软件建立体内屏障晶体结构模型及其制备方法和应用.夏红梅，徐银祥，程志清，刘亚琴.申请号: 201310005750.3
（3）紫草宁及其衍生物或修饰物的脂质体的制备方法及应用.杨永华，夏红梅，戚金亮，王小明，杨荣武，刘洪昌，浩日沁巴图，张靖靖，孔文尧.申请号：201110004511.7
（4）针刺幼苗茎节法高效诱导紫草毛状根的产生及应用. 戚金亮，赵胡，夏红梅，杨永华，邹爱兰，刘洪昌，丁燕雯，朱煜.申请号：201010536031.0
四、主要研究方向,研究生带教情况
1. 主要研究方向
(1) 新型靶向生物制剂研制和抗氧化、抗炎症、抗肿瘤等药理活性分子机制、信号传导和生物软件分析等研究。
(2) 植物(川芎,白芍,凤丹,石斛,山萘,黄精,姜黄等)苗、组织和细胞转基因体系的建立和次生代谢产物(川芎嗪,芍药苷,丹皮酚,黄酮,槲皮素,姜黄素等)的基因调控机制等。
(3) 药食同源产品的开发和应用等。
2.研究生带教情况
(1)已毕业研究生多人
(2)现在正带教的研究生有16人
五、联系方式
邮箱：sm_shine@ahtcm.edu.cn
sm_shine@163.com
微信：T1035077804
QQ：1035077804
