
一、个人简历
孙亚楠,女,生物化学与分子生物学博士,教授(校聘),博士生导师。
本科毕业于电⼦科技⼤学⽣命科学学院,获学⼠学位;博士阶段在北京⽣命科学研究所与北京师范⼤学联合培养,获博⼠学位。此后在波⼠顿医学中⼼从事科研工作,师从波⼠顿⼤学⾎液与肿瘤系崔帅英教授。以第⼀作者⾝份在国际知名期刊 Science Advances (2024), British Journal of Haematology (2022), eLife (2020)等杂志上发表研究论⽂。2023年获得美国Cooley’s 贫⾎基⾦会的研究基⾦ ,并受邀担任2024-2025 年度hLife杂志青年编委。
二、教学科研情况(包括主要在研课题、获奖成果等)
1. 国家自然科学基金委员会青年科学基金项目,HMI-lncRNA在胎儿血红蛋白表达调控中的分子机制和作用研究,主持,2026.01-2028.12
2. 美国Cooley’s贫血基金会研究基金,Evaluation of the in vivo therapeutic effects of SR-18292, 主持,2023.07-2024.06
三、论著情况(包括代表性论文、专著、教材)
1. Sun Y, Benmhammed H, Alabdullatif S, Habara A, Fu E, Brady J, Williams C, Ilinski A, Sharma A, Mahdaviani K, Alekseyev Y, Campbell J, Steinberg M, Cui S. PGC-1α agonism induces fetal hemoglobin and exerts anti-sickling effects in sickle cell disease. Science Advances. 2024; DOI: 10.1126/sciadv.adn8750.
2. Sun Y, Habara A, Le C, Nguyen N, Chen R, Chui D, Steinberg M, Cui S. Pharmacologic induction of PGC-1α stimulates fetal hemoglobin gene expression. British Journal of Haematology. 2022;00:1–13. DOI: 10.1111/bjh.18042.
3. Sun Y, Li M, Zhao D, Li X, Yang C, Wang X. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. eLife. 2020;9:e55745.
4. Duan, J*, Sun Y*, J. D. Matute and R. S. Blumberg. Characterizing CD4 T cell differentiation in mouse small intestine using T cell transfer, lamina propria preparation, and flow cytometry." STAR Protocols. 2023; 4(3): 102485. (*co-first author)
5. Li X*, Sun Y*, Wang X. Probing lysosomal activity in vivo. Biophysics Reports. 2021;7(1):1-7. (*co-first author)
6. Myers G, Sun Y, Wang Y, Benmhammed H, Cui S. Roles of Nuclear Orphan Receptors TR2 and TR4 during Hematopoiesis. Genes. 2024;15(5), 563.
7. Aygun B, Bello A, Thompson A, Davis L, Sun Y, Luo H, Cui S, Chui D. Clinical phenotypes of three children with sickle cell disease caused by HbS/Sicilian (δβ)0-thalassemia deletion. American Journal of Hematology. 2022;Jan 19. doi: 10.1002/ajh.26470.
8. Wang Z, Zhao H, Yuan C, Zhao D, Sun Y, Wang X, Zhang H. The RBG-1/RBG-2 complex modulates autophagy activity by regulating lysosomal biogenesis and function. Journal of Cell Science. 2019; 234195.
9. Li Y, Chen B, Zou W, Wang X, Wu Y, Zhao D, Sun Y, Liu Y, Chen L, Miao L, Yang C, Wang X. The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity. Journal of Cell Biology. 2016;215(2):167-185.
三、主要研究方向,研究生带教情况
主要研究方向为⾎红蛋⽩在⽣理发育过程中的转换机制,致⼒于为镰⼑型贫⾎症和地中海贫⾎等⾎液疾病的治疗探索新策略。
五、联系方式:
邮箱:sunyanan2020@gmail.com