导师简介-周婷婷

发布者:研究生院 发布时间:2022-11-10 浏览次数:

周婷婷19806生,博士,海军军医大学药学院药物分析学教研室主任教授,博士生导师;上海市药物(中药)代谢产物研究重点实验室主任海军军医大学本科生创新实践能力孵化基地负责人上海市优秀青年教师,吴孟超式优秀青年,“深蓝”人才工程“领航”人才,上海市卫健委卫生健康学科带头人。研究方向为中药药效物质及代谢研究。兼任上海大学教授、硕士生导师;安徽中医药大学教授、硕士生导师;福建中医药大学教授硕士生导师;中国药学会药物分析专业委员会委员;上海市药学会第12届理事会理事;上海市药学会药物分析专业委员会副主任委员;世界中医药学会联合会中药系统科学与工程分会常务理事;高等学校《中药分析》课程联盟理事;中华中医药学会中药分析分会委员;中国仪器仪表学会药物质量分析与过程控制分会理事;中国医药生物技术协会药物分析技术分会委员。

主持包括4项国家自然科学基金以及其他省部级项目等10以第一/通讯作者发表论文60篇,其中SCI收录论文31篇,总影响因子181.704分,单篇最高影响因子14.026,5分以上16篇总引用次数2000余次,单篇最高被引1152。申请国家发明专利15项,10项获授权;第一完成人的研究成果“基于药效物质、指纹特征及体内代谢过程的中药全面质量控制技术体系”获上海市药学科技奖二等奖。培养博士与硕士研究生23名。担任Frontiers in pharmacology杂志(SCI IF=5.988)客座主编;Journal of pharmaceutical analysis杂志(SCI IF=14.026)青年编委;英文期刊 Acupuncture and Herbal Medicine 青年编委;《药物分析杂志》、《沈阳药科大学学报》、《中草药》、《世界科学技术-中医药现代化杂志》等杂志编委。

指导本科生获省部级以上科技竞赛奖励40余项,其中国家级科技竞赛奖励7项,包括第十届全国大学生药苑论坛创新成果特等奖、优秀壁报奖、优秀论文奖;第五届、第六届全国大学生基础医学创新论坛优秀成果奖一等奖、三等奖作为第一完成人的成果“药学本科创新能力培养多元化、阶梯式教学模式改革与实践”获上海市优秀教学成果奖一等奖;担任海军级精品课程《药物分析》负责人主持军队级等教学平台/教改课题8510万元主编副主编、参编国家级规划教材10余获全国高等学校药学类青年教师教学能力大赛、微课大赛一等奖各1项。

附1:主持科研项目情况

(1)国家自然科学基金面上项目,81973457,栀子豉汤中淡豆豉调控肠道菌群微生态降低栀子肝脏毒性的分子机制研究,2020.01-2023.12,54万,在研,主持

(2)国家自然科学基金面上项目,81773862,栀子豉汤通过肠道菌群-肠-脑轴介导的抗抑郁作用机制及其药效物质基础研究,2018.01-2019.12,25万,结题,主持

(3)国家自然科学基金面上项目,81573584,栀子豉汤多成分多靶点神经保护作用机制及其药效物质基础研究,2016/01-2019/12,60万,结题,主持

(4)国家自然科学基金青年项目,30801541,基于多维色谱-质谱联用技术的栀子总环烯醚萜苷代谢指纹特征研究,2009/01-2011/12,20万元,结题,主持

(5)上海高校优秀青年教师科研专项基金项目,沪教委人[2010]83号,栀子总环烯醚萜苷代谢指纹特征研究,2010/12-2012/12,5万元,结题,主持

6)上海市科委科技行动创新计划,21S21902400,抗抑郁栀子豉汤颗粒临床前研究,2021.8-2024.7,40万,在研,主持

7)上海市卫生健康委员会卫生健康学科带头人计划,肠道菌群调控的栀子豉汤配伍减毒增效作用机制研究,2022.7-2025.6,45万,在研,主持

2第一/通讯作者发表SCI论文情况:

(1)Yusha Luo, Tingting Zhou*. Connecting the dots: targeting the microbiome in drug toxicity. Medicinal Research Reviews. 2022,42:83-111. (Impact factor:12.388)

(2)Jialin Liu#, Yichao Fang#, Lixun Cui#, Zhongzhao Wang, Yusha Luo, Congcong Gao, Wen Ge, Taohong Huang, Jun Wen, Tingting Zhou*. Butyrate emerges as a crucial effector of Zhi-Zi-Chi decoctions to ameliorate depression via multiple pathways of brain-gut axis. Biomed Pharmacother. 2022, 149:112861. (Impact factor:7.419)

(3)Yin Zhang#, Yichao Fang#, Lixun Cui#, Yuetong Jiang, Yusha Luo, Wen Zhang, Dexun Yu, Jun Wen*, Tingting Zhou*. Zhi-zi-chi decoction reverses depressive behaviors in CUMS rats by reducing oxidative stress injury via regulating GSH/GSSG pathway. Frontiers in Pharmacology. 2022,13: 887890. (Impact factor:5.988)

(4)Yusha Luo#, Fangyuan Gao#, Ruirui Chang#, Xingjie Zhang, Jie Zhong, Jun Wen*, Jianlin Wu*, Tingting Zhou*. Metabolomics Based Comprehensive Investigation of Gardeniae Fructus Induced Hepatotoxicity. Food and Chemical Toxicology. 2021, 153:112250.(Impact factor:5.572).

(5)Yusha Luo#, Xingjie Zhang#, Wen Zhang#, Qiliang Yang, Wei You, Jun Wen*, Tingting Zhou*.Compatibility with Semen Sojae Praeparatum attenuates hepatotoxicity of Gardeniae Fructus by regulating the microbiota, promoting butyrate production and activating antioxidant response.Phytomedicine.2021,90:153656.(Impact factor:6.656).

(6)Fang-Yuan Gao#, Hai-Yan Chen#, Yu-Sha Luo#, Ji-Kuai Chen, Lang Yan, Jiang-Bo Zhu*, Guo-Rong Fan*, Ting-Ting Zhou*.Q-markers targeted screening” strategy for comprehensive qualitative and quantitative analysis in fingerprints of Angelica dahurica with chemometric methods. Food Chemistry: X. 12 (2021) 100162 (Impact factor:6.443)

(7)Yin Zhang# , Yusha Luo#, Dongqi Zhang, Bo Pang, Jun Wen*, Tingting Zhou*. Predicting a Potential Link to Antidepressant Effect: Neuroprotection of Zhi-zi-chi Decoction on Glutamate-induced Cytotoxicity in PC12 Cells. Frontiers in Pharmacology. 2021, 11:625108.(Impact factor:5.988).

(8)Ruirui Chang#, Jialin Liu#, Yusha Luo#, Taohong Huang, Qi Li, Jun Wen*, Weidong Chen*, Tingting Zhou*. Isoflavones' effects on pharmacokinetic profiles of main iridoids from Gardeniae Fructus in rats. Journal of Pharmaceutical Analysis. 2020, 10:571-580.(Impact factor:14.026).

(9)Yin Zhang#, Yuan Yao#, Xiaolei Shi, Jun Fan, Taohong Huang, Jun Wen, Tingting Zhou*.Combination of cell metabolomics and pharmacology: A novel strategy to investigate the neuroprotective effect of Zhi-zi-chi decoction, Journal of Ethnopharmacology, 2019, 236:302-315.(Impact factor:5.195).

(10)Hui Guo#, Zhen Zhang#, Yuan Yao, Jialin Liu, Ruirui Chang, Zhao Liu, Hongyuan Hao, Taohong Huang, Jun Wen, Tingting Zhou*. A new strategy for statistical analysis-based fingerprint establishment: Application to quality assessment of Semen sojae praeparatum. Food Chemistry, 2018, 258: 189-198.(Impact factor:9.231).

(11)Jialin Liu#, Ruirui Chang#, Xiaobei Zhang, Zhongzhao Wang, Jun Wen, Tingting Zhou*. Non-isoflavones Diet Incurred Metabolic Modifications Induced by Constipation in Rats via Targeting Gut Microbiota. Frontiers in Microbiology, 2018, 9: 3002.(Impact factor:6.064).

(12)Yuan Yao#, Xin Ma#, Teng Li#, Hui Guo, Ruirui Chang, Jialin Liu, Qiaoxia Liu, Hongyuan, Hao, Taohong Huang, Weidong Chen*, Jun Wen*, Tingting Zhou*. Quantification of isoflavone glycosides and aglycones in rat plasma by LC-MS/MS: Troubleshooting of interference from food and its application to pharmacokinetic study of Semen Sojae Praeparatum extract. Journal of Pharmaceutical and Biomedical Analysis, 2018, 161:444-454.(Impact factor:3.571).

(13)Xiuxiu Li#, Jun Wen, Jingjing Jiang, Xin Zhao, Tingting Zhou*, Guorong Fan*. Quantification of a Novel Photosensitizer of Chlorin e6-C15-Monomethyl Ester in Beagle Dog Plasma Using HPLC: Application to Pharmacokinetic Studies. Molecules, 2017, 22:693.(Impact factor:4.927).

(14)Guang Yang#, Xin Zhao#, Jun Wen, Tingting Zhou*, Guorong Fan*. Simultaneous fingerprint, quantitative analysis and anti-oxidative based screening of components in Rhizoma Smilacis Glabrae using liquid chromatography coupled with Charged Aerosol and Coulometric array Detection. Journal of Chromatography B, 2017, 1049:41-50.(Impact factor:3.318).

(15)Fangyuan Gao#, Tingting Zhou#, Yongsheng Hu#, Liai Lan, Yvan Vander Heyden, Jacques Crommen, Guocai Lu*, Guorong Fan*. Cyclodextrin-based ultrasonic-assisted microwave extraction and HPLC-PDA-ESI-ITMSn separation and identification of hydrophilic and hydrophobic components of Polygonum cuspidatum: a green, rapid and effective process, Industrial Crops and Products, 2016, 80: 59-69.(Impact factor:6.449).

(16)Yuqing Cao#, Jun Wen#, Tingting Zhou*, Guorong Fan*. On-Line Organic Solvent Field Enhanced Sample Injection in Capillary Zone Electrophoresis for Analysis of Quetiapine in Beagle Dog Plasma, Molecules, 2016, 21, 121-130.(Impact factor:4.927).

(17)Fangyuan Gao#, Zihua Xu#, Weizhong Wang, Guocai Lu, Yvan Vander Heyden, Tingting Zhou*, Guorong Fan*. A comprehensive strategy using chromatographic profiles combined with chemometric methods: Application to quality control of Polygonum cuspidatum Sieb. et Zucc, Journal of Chromatography A, 2016, 1466: 67-75.(Impact factor:4.601).

(18)Yan Han#, Jun Wen, Tingting Zhou*, Guorong Fan*. Chemical fingerprinting of Gardenia jasminoids Ellis by HPLC-DAD-ESI-MS combined with chemometrics methods, Food Chemistry,2015: 188: 648-657.(Impact factor:9.231).

(19)Guang Yang#, Qiushi Sun#, Zhiyan Hu, Hua Liu, Tingting Zhou*, Guorong Fan*. Optimization of an accelerated solvent extraction dispersive liquid–liquid microextraction method for the separation and determination of essential oil from Ligusticum chuanxiong Hort by gas chromatography with mass spectrometry, Journal of Separation Science. 2015, 38: 3588–3598.(Impact factor:3.614).

20Shanqiao Chen#, Xin Zhao#, You Li, Dan Yang, Tingting Zhou*, Guorong Fan*. Impurities preparation of Sodium Tanshinone IIA Sulfonate by high-speed counter-current chromatography and identification by liquid chromatography/ multistage tandem mass spectrometry. Journal of Chromatography A. 2013, 1288:28-34.(Impact factor:4.601).

(21)Z. Liu#, Y. Luo#, T.-T. Zhou*, W.-Z. Zhang*. Could plant lectins become promising anti-tumourdrugs for causing autophagic cell death, Cell Proliferation, 2013, 46:509-515.(Impact factor:8.755).

(22)L. Ouyang#, Z. Shi#, S. Zhao#, F.-T. Wang, T.-T. Zhou*, B. Liu*, J.-K. Bao*, Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Proliferation. 2012, 45: 487-498.(Impact factor:8.755).

(23)Tingting Zhou#, Hua Liu, Jun Wen, Guorong Fan*. Fragmentation study of iridoid glycosides including epimers by liquid chromatography-diode array detection-electrospray ionization mass spectrometry and its application in metabolic fingerprint analysis of Gardenia jasminoides Ellis. Rapid Communications in Mass Spectrometry, 2010, 24: 2520-2528.(Impact factor:2.586).

(24)Zi-ting Zhang#, Hao Peng#, Chun-yang Li, Jun-jie Liu, Ting-Ting Zhou*, Yi-fang Yan, Yan Li, Jin-ku Bao*, Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis via a caspase-dependent pathway as compared to Ophiopogon japonicus lectin. Phytomedicine, 2010, 18: 25-31.(Impact factor:6.656).

(25)Honglei Xu#, Tingting Zhou#, Jun Wen, Guorong Fan*,Yutian Wu. Isolation and purification of three flavonoids from the hawthorn leaves by high-speed counter-current chromatography combined together with isocratic preparative reversed-phase high-performance liquid chromatography. Journal of Liquid Chromatography & Related Technologies, 2009, 32:2216-2231.(Impact factor:1.467).

(26)Tingting Zhou#, Zhenyu Zhu#, Chen Wang#, Guorong Fan*,Jingyong Peng, Yifeng Chai, Yutian Wu. On-line purity monitoring in high-speed counter-current chromatography: Application of HSCCC-HPLC-DAD for the preparation of 5-HMF, neomangiferin and mangiferin from Anemarrhena asphodeloides Bunge. Journal of Pharmaceutical and Biomedical Analysis. 2007, 44: 96-100.(Impact factor:3.571).

(27)Tingting Zhou#, Weiquan Zhao, Guorong Fan*, Yifeng Chai, Yutian Wu. Isolation and purification of iridoid glycosides from Gardenia jasminoides Ellis by isocratic reversed-phase two-dimensional preparative high-performance liquid chromatography with column switch technology. Journal of Chromatography B. 2007, 858:296-301.(Impact factor:3.318).

(28)Weiquan Zhao#, Tingting Zhou#, Guorong Fan*, Yifeng Chai, Yutian Wu. Isolation and purification of lignans from Magnolia biondii Pamp by isocratic reversed-phase two-dimensional liquid chromatography following microwave-assisted extraction. Journal of Separation Science. 2007, 30:2370-2381.(Impact factor:3.614).

(29)Bo Ding#, TingTing Zhou#, Guorong Fan*, Zhanying Hong, Yutian Wu. Qualitative and quantitative determination of ten alkaloids in traditional Chinese medicine Corydalis yanhusuo W. T. Wang by LC-MS/MS and LC-DAD. Journal of Pharmaceutical and Biomedical Analysis, 2007, 45: 219-226.(Impact factor:3.571).

(30)Tingting Zhou#, Bin Chen#, Guorong Fan*, Yifeng Chai, Yutian Wu. Application of high-speed counter-current chromatography coupled with high-performance liquid chromatography-diode array detection for the preparative isolation and purification of hyperoside from Hypericum perforatum with online purity monitoring. Journal of Chromatography A. 2006, 1116: 97-101.(Impact factor:4.601).

(31)Tingting Zhou#, Guorong Fan*, Zhanying Hong, Yifeng Chai, Yutian Wu. Large-scale isolation and purification of geniposide from the fruit of Gardenia jasminoides Ellis by high-speed counter-current chromatography. Journal of Chromatography A. 2005, 1100: 76-80.(Impact factor:4.601).

3:获奖情况:

1)2022年上海市优秀教学成果奖一等奖(第一完成人),上海市政府授予。

22018年度上海市药学科技奖二等奖(第一完成人),上海市药学会授予。

(3)2019高等学校药学类青年教师微课教学大赛一等奖(第一完成人),教育部高等学校药学类专业教学指导委员会授予。

(4)2019高等学校药学类青年教师教学能力大赛一等奖(第一完成人),教育部高等学校药学类专业教学指导委员会授予。

(5)2017第十届全国大学生药苑论坛创新成果特等奖(第一指导老师),教育部高等学校药学类专业教学指导委员会、中国高等教育学会医学教育专业委员会药学教育研究会授予。

(6)2017第十届全国大学生药苑论坛优秀论文奖(第一指导老师),教育部高等学校药学类专业教学指导委员会、中国高等教育学会医学教育专业委员会药学教育研究会授予。

(7)2017第十届全国大学生药苑论坛优秀壁报奖(第一指导老师),教育部高等学校药学类专业教学指导委员会、中国高等教育学会医学教育专业委员会药学教育研究会授予。

(8)2018第五届全国大学生基础医学创新论坛暨实验设计大赛一等奖(第一指导老师),高等学校国家级实验教学示范中心联席会授予。

(9)2020第六届全国大学生基础医学创新论坛暨实验设计大赛三等奖(第一指导老师),高等学校国家级实验教学示范中心联席会授予。

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