导师简介-陈乃东

发布者:研究生院 发布时间:2023-12-13 浏览次数:


一、个人简历

陈乃东,男,19729月出生,安徽金寨人,博士、教授,硕导,皖西学院生物与制药工程学院副院长、皖西学院博士后科研工作站站长、中药质量评价与品质提升安徽省重点实验室主任,安徽省特支计划领军人才。主持国家自然基金、中央财政林业科技推广项目、安徽省重大专项等国家级、省部级项目20余项,共发表学术论文140余篇,申请专利40余项,主持/参与制定行业标准/地方标准18项。安徽省植物学会常务理事、安徽省药学会制药工程专业委员会副主任委员。

研究成果获安徽省科技进步二等奖2项、全国商业联合会科技进步特等奖1项、安徽省教学成果二等奖1项。

二、研究方向

主要研究方向:中药质量评价、品质提升与中药创新药物研究。

三、代表性教科研项目

 5年主持的代表性科研项目:

1.安徽省重点研发项目《江淮果岭三桃一梨产品高值加工与品质保持共性关键技术研究与产业化》(2023n06020004), 执行期:2023-2026

2. 2023年安徽省中医药科技攻关项目《霍山石斛道地性成因研究与品质提升模式构建》子课题(202303a0702005),执行期:2023-2027

3.《安徽省中药质量评价与品质提升科研创新团队》项目(2022AH010090),执行期:2022-2025

4.安徽省科技重大专项:《霍山石斛品质提升关键技术集成示范与产业化研究》(201903a07020017),执行期:2019-2022

5.央财林业科技推广项目《特色木本药材绿萼梅与元胡和地黄复合经营技术推广示范》,执行期:2021-2023

6.安徽省特支计划(第6批)项目,执行期:2020-2022

7.六安市叶集区艾鑫增源农业发展有限责任公司产学研合作项目:《复方艾叶敷贴片生产工艺研究》,执行期:2021-2024

8.山东博华生物科技有限责任公司产学研合作项目:《北方石斛种植模式研究》,执行期:2016-2018

9.安徽省斛生记生物有限公司《石斛速溶粉加工工艺研究》,执行期:2022.1-2022.12

10.安徽安立肽生物科技有限公司《一款石斛基降尿酸功效口服液研究》,执行期:2023.1-2.23.8

四、科研成果

(一) 5年发表的代表性学术论文

[1]Dao-Yuan Li, Run Wang, Meng You, Nai-Dong Chen(通讯)Li Sun, Nai-Fu Chen. The antimicrobial effect and mechanism of the Artemisia argyi essential oil against bacteria and fungus [J]. Brazilian Journal of Microbiology,2023. IF:2.2.

[2]Wei-Han Yang, Jing-Wen Hao, Nai-Dong Chen(通讯), Jiao Li. Development of a joint derivatization protocol for the unequivocal identification of the monosaccharide composition in four Dendrobium polysaccharides and free monosaccharide by GC-MS [J]. Biomedical Chromatography, 2023. IF:1.8

[3]Hao, Jing-Wen; Nai‐Dong Chen(通讯); Liu, Xiao-Quan; Li, Qiang; Xu, Hui-Min; Yang, Wei-Han; Qin, Chao-Feng; Bu, Ya-Qing. Detection of the adulteration of Dendrobium huoshanense with Dendrobium henanense by UV-vis-shortwave near-infrared diffuse reflectance spectroscopy combined with chemometrics [J]. Journal of AOAC International, 2023. IF: 1.913

[4] Xiao-Quan Liu, Chao-Feng Qin, Nai‐Dong Chen(通讯), et al. Simultaneous determination of phenols in the four main original plants of the famous traditional Chinese medicine Shihu by pressurized capillary electrochromatography[J]. RSC Advances, 2023. IF: 3.9

[5] Guo-Si Li, Fu-Cheng Zhu, Fang-Li Gu, Xin-Jian Yin, Qi-Lin Xu, Meng-Hua Ma, Li Zhu, Bao-Wei Lu, Nai-Dong Chen(通讯). Enzymatic Preparation of L-Malate in a Reaction System with Product Separation and Enzyme Recycling [J].Catalysts, 2022.  IF:4.501

[6]An-Ling Zhu, Jing-Wen Hao, Lei Liu, Qi Wang, Nai-Dong Chen(通讯),  Guang-Lin Wang. Simultaneous Quantification of 11 Phenolic Compounds and Consistency Evaluation in Four Dendrobium Species Used as Ingredients of the Traditional Chinese Medicine Shihu[J]. Frontiiers in Nutrition, 2021. IF:6.576

[7]Jing-Wen Hao, Xiao-Quan Liu, Nai-dong Chen(通讯), et al. Simultaneous analysis of 20 free amino acids by a single marker combined with an HPLC fingerprint evaluation of Dendrobium huoshanense[J].Journal of Food Science,2021. IF:3.167

[8]Jing-Wen Hao, An-Ling Zhu, Nai-Dong Chen (通讯), et al. Simultaneous determination of 16 important biologically active phytohormones in Dendrobium huoshanese by Pressurized Capillary Electrochromatography[J]. Journal of Chromatography B, 2021. IF:3.205

[9]Jing-Wen Hao, Xiao-Quan Liu, Nai-Dong Chen(通讯), et al. Solid-phase extraction followed by direct TOF-MS-MS and HPLC analysis of ptaquiloside in Pteridium aquilinum from different places of China [J]. Journal of Food Composition and Analysis, 2021. IF:4.556

[10]Jing-Wen Hao, An-Ling Zhu, Nai-Dong Chen(通讯), et al. Rapid detection of adulteration in Dendrobium huoshanense with Dendrobium henanense by ATR-FTIR combined with multivariate methods[J]. Iranian Journal of Pharmaceutical Research, 2021. IF:1.696

[11]Jing-Wen Hao, Yue Chen, Nai-Dong Chen(通讯), et al. Assessment of ATR-NIR and ATR-MIR spectroscopy as an analytical tool for the quantification of the total polyphenols in Dendrobium huoshanense[J]. Phytochemical Analysis, 2020. IF: 3.373

[12]Jing-Wen Hao, Yue Chen, Nai-Dong Chen通讯,et al. Rapid detection of adulteration in Dendrobium huoshanense using NIR spectroscopy coupled with chemometric methods[J]. Journal of AOAC International2020. IF: 1.913

[13]Nai-Dong Chen. Combined application of Fourier-transform Infrared, the Discrimination of the flower tea of Dendrobium huoshanense, Dendrobium officinale by a multi-step FTIR method[J]. Spectroscopy and Spectral Analysis, 2020. IF: 0.452

[14] Nai-Dong Chen, Yue Chen, Li Zhang, et al. Combined application of Fourier-transform Infrared, Second Derivative Infrared, and Two-dimensional Correlation Infrared Spectroscopy to monitor the quality of Dendrobium huoshanense during processing[J]. Current Topics in Nutraceutical Research, 2020. IF: 0.416

[15]Nai-Dong Chen, Yue Chen, Zhang, Li, et al. Principal component analysis-based strategy to identify the presence of tissue-cultured and wild-type Dendrobium officinale and Dendrobium moniliforme in a commercial preparation[J]. Current Topics in Nutraceutical Research, 2019. IF: 0.416

[16]Jing-Wen Hao, Nai‐Dong Chen(通讯), Xu-Cheng Fu, et al. Predicting the contents of polysaccharides and its monosugars in Dendrobium huoshanense by partial least squares regression model using attenuated total reflectance fourier transform infrared spectroscopy[J]. Spectroscopy Letters, 2019. IF: 1.179

[17]Jing-Wen Hao, Nai-Dong Chen (通讯), Cun-Wu Chen,et al. Rapid quantification of polysaccharide and the main monosaccharides in Dendrobium huoshanense by near-infrared attenuated total reflectance spectroscopy[J]. Journal of Pharmaceutical and Biomedical Analysis, 2018. IF:3.935

[18]Hua-Yang Si, Nai-Fu Chen, Nai-Dong Chen (通讯), et al. Structural characterisation of a water-soluble polysaccharide from tissue-cultured Dendrobium huoshanense C.Z. Tang et S.J.Cheng[J]. Natural Product Research, 2018. IF:2.861

(二)近5年代表性授权专利

[1] 2023年授权发明专利《一种蕨菜中原蕨苷的分离纯化制备方法R1

[2] 2022年授权发明专利《一种蕨菜中原蕨苷含量的检测方法R1

[3]2021年授权发明专利《一种利用微生物转化山奈酚生产紫云英苷的方法》,R1

(三)代表性标准

[1]安徽地方标准《霍山石斛枫斗质量检测技术规程》(DB34/T 2938-2017),R1

[2]安徽地方标准《霍山铁皮石斛枫斗质量检测技术规程》(DB34/T 2937-2017),R1

(四)代表性成果鉴定

[1]安徽省成果鉴定《霍山石斛品质提升关键技术集成示范与产业化研究》(2023F021J002634),R1

[2] 安徽省成果鉴定《霍山石斛枫斗炮制工艺条件及炮制过程中品质控 制方法研究》(2019F051Y000608),R1

[3] 安徽省成果鉴定《霍山石 ,铁皮石斛与河南石斛花茶多级红外光谱快速鉴定研究》(2021F021J002953),R1

五、近年来获省部级以上奖励情况

12021年,获安徽省科技进步二等奖《大别山林药复合经营关键技术及集成示范研究》,第一完成人

22020年,获评安徽省特支计划领军才,授予单位:安徽省委组织部

32022年,安徽省教学成果二等奖《多措并举、研学融合,培养应用型制药人才》,第一完成人

六、指导研究生情况

硕士生在读15人。

七、联系方式

电话:0564-3305073邮箱:2004cnd@163.com