陈娟,女,博士,副教授,硕士生导师,现药剂系专任教师。安徽中医药大学高层次人才,近年一直从事中药制剂物质基础和药效评价等研究,尤其在中药多糖组分研究方面具有扎实的的理论基础和丰富的实践基础。主持安徽省自然科学青年基金、安徽省教育厅自然科学类重点项目等科研项目5项,以一作(共同)或通讯作者在Food Funct、Int J BiolMacromol、J Ethnopharmacol、Biomedicine & Pharmacotherapy等国际期刊发表SCI论文10篇,以第一发明人授权国家发明专利1项,副主编专著1部。
【主持项目】
1.安徽省自然科学基金青年项目:基于碳水化合物酶“桥梁”作用的桔梗多糖与肠道菌群互作调控脂代谢的结构基础研究,2208085QC98,2022.01-2023.12,10万
2.安徽省教育厅自然科学重点项目:基于CAZymes响应的肠道菌群生物转化研究桔梗多糖-皂苷双组分治疗慢性支气管炎的协同增效机制,2023AH050826,2023.08-2025.08,10万
3.安徽中医药大学人才支持计划(重点项目):基于体外抗消化和酵解特征的桔梗多糖的益生元特性研究,2020rczd005,2020.11-2026.11,20万
【代表性论文】
1.Xu C, Hao MQ, Zai XH, Song J, Huang YZ, Gui SY, Chen J*. A new perspective on gut-lung axis affected through resident microbiome and their implications on immune response in respiratory diseases[J]. Arch Microbiol. 2024,206(3):107.
2.Jing Song; Qin liu; Mengqi Hao; Xiaohu Zhai; Juan Chen*. Effects of neutral polysaccharide from Platycodon grandiflorum on high-fat diet-induced obesity via the regulation of gut microbiota and metabolites, Front Endocrinol (Lausanne). 2023;14:1078593.
3.Juan Chen, Jiaojiao Liu, Chenchen Yan, Chan Zhang,Wenjuan Pan, Wenna Zhang, Yongming Lu, Lei Chen and Yan Chen*, Sarcodon aspratus polysaccharides ameliorated obesity-induced metabolic disorders and modulated gut microbiota dysbiosis in mice fed a high-fat diet[J]. FOOD & FUNCTION. 2020,11(3):2588-2602.
4. JiaoJiao Liu#, Juan Chen#, Ya Wang, ChenChen Yan, Chan Zhang, Shomaila Mehmood, WenJuan Pan,WenNa Zhang,YongMing Lu, QingXi Wu, Lei Chen, Yan Chen*. Reduction of 5-fluorouracil-induced toxicity by Sarcodon aspratus polysaccharides in Lewis tumor-bearing mice[J]. International Journal of Biological Macromolecules. 2020,163:232-239.
5.Juan Chen#, Minghua Zhang#, Maomao Zhu, Junfei Gu,Jie Song, Li Cui, Dan Liu,Qing Ning,Xiaobin Jia and Liang Feng*, Paeoniflorin prevents endoplasmic reticulum stress-associated inflammation in lipopolysaccharide-stimulated human umbilical vein endothelial cells via the IRE1α /NF-κB signaling pathway[J]. FOOD & FUNCTION. 2018,9(4):2386-2397.
招收中药学(学硕、专硕)研究生,欢迎报考!邮箱:chenjuan@ahtcm.edu.cn