一、个人简历
教育经历:
2002.09 - 2006.06:第二军医大学,药学,学士
2006.09 - 2011.06:第二军医大学,生药学,博士
任职经历:
2011.07 - 2018.11: 海军军医大学第二附属医院药剂科,主管药师
2018.12 - 至今:海军军医大学第二附属医院药剂科,副主任药师,副教授
2021.12 - 至今:海军军医大学第二附属医院药剂科,副主任
二、教学科研情况
主要在研课题:
[1] 国家自然科学基金,黄葵调控内源性毒素肾脏合成和转运功能改善他克莫司肾毒性的机理和药效物质研究(82274059),主持
[2] 国家重点研发计划子课题,临床证据导向的丹参、党参“功效-物质”全景解析及深度研发(2022YFC3501702),主持
[3] 上海市科委科技成果转化和产业化项目,治疗心律失常制剂益心饮的临床前研究(22S21901900),主持
[4] 海军军医大学远航人才,海军军医大学“深蓝工程”重点人才培养,主持
[5] 院创新型临床研究资助,他克莫司肾毒性机制及预警生物标志物的发现(2020YLCYJ -Y25),主持
获奖成果:
[1] 2017年上海市优秀青年药师
[2] 2018年中国药学会施维雅青年医院药学奖(全国仅8名)
[3] 2019年上海市青年科技启明星
[4] 2021年上海药学科技奖二等奖1项(3)
[5] 2022年中国医药教育协会科学技术奖科技创新奖三等奖1项(2)
[6] 2022年深蓝工程重点人才培养对象
[7] 2023年军队医疗人员三类特殊津贴
[8] 2023年上海药学科技奖青年人才奖
三、论著情况
论文情况:
以第一/通讯作者在Pharmacol Res、Phytomedicine、J Ethnopharmacol、Int Immunopharmacol等期刊发表SCI论文39篇,核心期刊31篇,代表作如下:
[1] Wen T#, Liu X#, Pang T#, Li M, Jiao G, Fan X, Tang J, Zhang C, Wang Z, Yue X#, Chen W*, Zhang F*. The Efficacy of Chaihu-Guizhi-Ganjiang Decoction on Chronic Non-Atrophic Gastritis with Gallbladder Heat and Spleen Cold Syndrome and Its Metabolomic Analysis: An Observational Controlled Before-After Clinical Trial. Drug design, development and therapy, 18, 881–897. (IF=4.9)
[2] He YQ #, Zhou CC#, Jiang SG#, Lan WQ, Zhang F*, Tao X*, Chen WS*. Natural products for the treatment of chemotherapy-related cognitive impairment and prospects of nose-to-brain drug delivery. Frontiers in pharmacology, 15, 1292807. (IF=5.6)
[3] Fan XC#,Jiao GY#,Pang T#,Wen T,He ZQ,Han J*,Zhang F*,Chen WS*.Ameliorative Effects of Mangiferin Derivative TPX on Insulin Resistance via PI3K/AKT and AMPK Signaling Pathways in Human HepG2 and HL-7702 Hepatocytes[J].Phytomedicine,2023,114:154740.(IF:7.9)
[4] Jiao GY#,Fan XC#,Wang YJ,Weng N,Ouyang LL,Wang HQ,Pan SH,Huang DD,Han J,Zhang F*,Chen WS*.Dissection of the active ingredients and potential mechanism of Han-Shi-Yu-Fei-Decoction in treating COVID-19 based on in vivo substances profiling and clinical symptom guided network pharmacology[J].ACS Omega,2022,7(41):36598-36610.(IF=4.132)
[5] Zhang F#,Zhai JX#,Nan W,Gao J,Yin J*,Chen WS*.A comprehensive review of the main lignan components of Schisandra chinensis (North Wu Wei Zi) and Schisandra sphenanthera (South Wu Wei Zi) and the lignan-induced drug-drug interactions based on the inhibition of cytochrome P450 and P-glycoprotein activities[J].Frontier in Pharmacology,2022,13:816036.(IF=5.988)
[6] Fan XC,Han J*,Zhang F*,Chen WS*. Red yeast rice: a functional food used to reduce hyperlipidemia[J].Food Reviews International,2022:2043894.(IF= 6.043)
[7] Huang DD#,Jiang SG#,Du ZN#,Chen YH#,Xue D,Wang XJ,Li MS,Zhang F*,Chen WS*,Sun LN*.Analgesic and anti-arthritic activities of Polysaccharides in Chaenomeles speciosa[J].Front Pharmacol, 2022, 13, 744915. (IF=5.988)
[8] Du ZN#,Huang DD#,Shi PJ#,Dong ZY,Wang XJ,Li MS,Chen WS*,Zhang F*,Sun LN*.Integrated Chemical Interpretation and Network Pharmacology Analysis to Reveal the Anti-Liver Fibrosis Effect of Penthorum chinense[J].Front Pharmacol.,2022,13:788388.(IF=5.988)
[9] Huang CY#,Qiu S#,Fan XC#,Jiao GY,Zhou X,Sun M,Weng N,Gao SH,Tao X*,Zhang F*,Chen WS*. Evaluation of the effect of Shengxian Decoction on doxorubicin-induced chronic heart failure model rats and a multicomponent comparative pharmacokinetic study after oral administration in normal and model rats[J].Biomedicine & Pharmacotherapy,2021,144:112354.(IF=7.419)
[10] Zhu Sang#,Zhang F#,Shen AW#,Sun B,Xia TY,Chen WS*,Tao X*,Yu SQ*.Metabolomics evaluation of patients with stage 5 chronic kidney disease before dialysis,maintenance hemodialysis,and peritoneal dialysis[J].Frontiers in Physiology,2021,11:630646.(IF=4.755)
[11] Huang DD#,Du ZN#,Chen YH#,Dong ZY,Wang XJ,Li MS,Zhang F*,Chen WS*,Sun LN*.Bio-Guided isolation of two new hypoglycemic triterpenoid saponins from Polygonum capitatum[J].Drug Des Devel Ther. 2021,15: 5001-5010.(IF=4.319)
[12] He YQ#,Zhou CC#,Yu LY#,Wang L#,Deng JL,Tao YL,Zhang F*,Chen WS*.Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms[J]. Pharmacol Res. 2021,163:105224.(IF=10.334)
参编专著4部:
[1] 《厨余垃圾里的中草药》,科学出版社,ISBN:978-7-03-075755-5,2023.11
[2] 普通高等医学专科院校十二五规划教材《药理学》,第二军医大学出版社,2012.01
[3] 《常见疾病临床药学监护案例分析》恶性肿瘤分册,科学出版社,2018.06
[4] 《新编中国药材学》(第六卷),中国医药科技出版社,ISBN: 9787521419368,2020.07
[5] 海军官兵常见防病防治丛书,《航空母舰舰员常见疾病防治》.第二军医大学出版社,ISBN:9787548113904.2022.12
四、主要研究方向,研究生带教情况
主要研究方向:
(1)中药药效物质发现及活性评价
(2)临床药物代谢动力学
(3)基于代谢组学的标志物发现
研究生带教情况:
近四年,已培养和协助培养研究生7名,其中一名获上海市普通高等学校优秀毕业生称号;在读研究生:8名。
五、联系方式
办公电话:021-51322403
电子邮箱:fengzhangky@aliyun.com
通讯地址:上海市浦东新区蔡伦路1200号