导师简介-郭健

发布者:研究生院 发布时间:2025-03-10 浏览次数:

郭健,男,副教授,致公党党员,中药学博士,硕士生导师。主持国家自然科学基金、安徽省自然科学基金、安徽省高校自然科学研究项目等6项;以第一/通讯作者发表论文23篇,其中SCI收录21篇;授权发明专利6项;Advanced Science, International Journal of Pharmaceutics, International Journal of NanomedicineSCI期刊审稿人。

主要研究方向为中药制剂新技术与新剂型。通过研究中药功能组分的体内行为,挖掘中药组分对人体微生态的调节干预作用和其药剂学应用潜力,以先进的给药技术为主体,结合领先的制剂表征与体内外评价手段,对多种新型给药技术进行整合与创新,开发构建高效低毒的递药系统。

一、主持科研项目

(1) 国家自然科学基金青年项目,824048722025-01 2027-12, 30万元,主持

(2) 安徽省自然科学基金青年项目,2408085QH2852024-09 2026-09, 8万元,主持

(3) 安徽高校自然科学研究项目, 2023AH050785, 2023-08 2025-08, 10万元,主持

(4) 安徽高校自然科学研究项目, KJ2021A0538, 2022-01 2023-12, 6万元,主持

(5) 安徽中医药大学高层次人才支持计划项目,2022rczd003, 2022-01 2027-1220万元,主持

(6) 安徽中医药大学研究生培养基金,2022-01 2024-122万元,主持

二、近年来发表论文

(1) CCL2-scavenging nanodecoy hydrogel multi-step remodel monocytes recruitment and macrophages polarization for periodontitis treatment. Chemical Engineering Journal. 2024, 501,157660 (中科院一区TOP,通讯作者,IF=13.4)

(2) New insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regeneration, Journal of Nanobiotechnology. 2024; 22(1), 19. (中科院一区TOP,通讯作者,IF=10.2ESI高被引论文)

(3) Flavonoid extract from propolis alleviates periodontitis by boosting periodontium regeneration and inflammation resolution via regulating TLR4/MyD88/NF-κB and RANK/NF-κB pathway, Journal of Ethnopharmacology. 2024; 319, 117324.中科院一区TOP,通讯作者,IF=4.8

(4) Active targeting microemulsion-based thermosensitive hydrogel against periodontitis by reconstructing Th17/Treg homeostasis via regulating ROS-macrophages polarization cascade. International Journal of Pharmaceutics. 2024, 659,124263 (中科院二区TOP,通讯作者,IF=5.3)

(5) Ros-responsive and scavenging bifunctional hydrogel enables co-delivery of anti-inflammatory agent and osteogenetic nanoparticle for periodontitis treatment. Materials & Design. 2024; 239, 112777.(中科院二区TOP,通讯作者,IF=8.4

(6) Cubic liquid crystals containing propolis flavonoids as in situ thermo-sensitive hydrogel depots for periodontitis treatment: Preparation, pharmacodynamics and therapeutic mechanisms. European Journal of Pharmaceutical Sciences. 2024; 196, 106762 中科院二区通讯作者,IF=4.3

(7) Multi-functional D-alpha-tocopheryl polyethylene glycol succinate surface modified nanocrystals improve the stability and oral bioavailability of pueraria flavonoids. Journal of Drug Delivery Science and Technology. 2024; 95, 105623 (中科院三区通讯作者,IF=4.5

(8) ROS-responsive caffeic acid phenethyl ester-conjugated carboxymethyl chitosan hydrogel for treatment of periodontitis. Journal of Drug Delivery Science and Technology. 2024, 101,106255. (中科院三区,通讯作者,IF=4.5)

(9) Smart stimuli-responsive hydrogels for drug delivery in periodontitis treatment, Biomedicine & Pharmacotherapy. 2023; 162, 114688.中科院一区TOP,通讯作者,IF 7.5ESI高被引论文)

(10) Simultaneously boosting inflammation resolution and osteogenic differentiation in periodontitis using folic acid-modified liposome-thermosensitive hydrogel composites, Materials & Design. 2023; 234, 112314.中科院二区TOP,通讯作者,IF=8.4

(11) Microemulsion-thermosensitive gel composites as in situ-forming drug reservoir for periodontitis tissue repair through alveolar bone and collagen regeneration strategy, Pharmaceutical Development and Technology. 2023; 28(1), 30–39.中科院四区,通讯作者,IF=3.4

(12) Thermosensitive acetylated carboxymethyl chitosan gel depot systems sustained release caffeic acid phenethyl ester for periodontitis treatment, Polymers Advanced Technologies. 2023; 34(1), 155–165.中科院三区,通讯作者,IF=3.348

(13) A CFH peptide-decorated liposomal oxymatrine inactivates cancer-associated fibroblasts of hepatocellular carcinoma through epithelial–mesenchymal transition reversion, Journal of Nanobiotechnology. 2022; 20(1), 114.中科院一区TOP,第一作者,IF 9.429

(14) Sorafenib-loaded PLGA-TPGS nanosystems enhance hepatocellular carcinoma therapy through reversing P-glycoprotein-mediated multidrug resistance, AAPS PharmSciTech. 2022; 23(5), 130.中科院三区,通讯作者,IF=4.026

三、专利

(1) 一种叶酸修饰的槲皮素-薄荷油微乳温敏凝胶、制备方法及其应用, ZL202311511850.3,第1

(2) 一种双响应槲皮素-咖啡酸苯乙酯脂质复合凝胶及其制备方法和应用,ZL 202410596835.1,第1

(3) 一种载双组分智能响应凝胶的制备方法及应用,ZL202310192240.5,第4

(4) 一种多组分载药原位液晶及其制备方法和应用,ZL202211211346.7,第4

(5) 一种石斛口含片及其制备方法,ZL202210190207.4,第4

(6) 抗肝癌微乳纳米组合物及其应用. ZL202010341896.5,第3

四、参编教材、专著:

(1) 中药产品与开发,科学出版社,十四五普通高等教育中医药系列规划教材

(2) 中药新药研究与开发,科学出版社,十四五普通高等教育研究生规划教材

(3) 药物新剂型与制剂新技术,合肥工业大学出版社

五、招生与联系方式

招收中药学(学硕、专硕)研究生,研究方向为中药制剂新技术与新剂型,课题组氛围友好,仪器平台先进,支持研究生发表高水平论文。

联系邮箱:guoj0719@126.com.