曹曦，女，博士，校聘副教授，药学专业硕士生导师，现于安徽医科大学第一附属医院药剂科工作。2018年毕业于四川大学华西药学院，获理学博士学位。在研究生及工作期间一直从事靶向药物传递系统研究，目前主要围绕以下方向开展药剂学研究工作：1）药物载体的设计及其靶向性考察；2）靶向性机制研究。目前带教在读研究生5人。

一、近年主持科研项目情况：

1. 国家自然科学基金，青年科学基金项目，多功能脂质囊泡调控巨噬细胞极化用于治疗伴胰岛素抵抗的肥胖症研究”，82204290，2023-01-01至2025-12-31，在研，主持

2. 国家自然科学基金，面上项目，82174011，基于AMPK-Src/Tensin-整合素αⅡbβ3双向信号通路探讨莪术二酮调控血小板活化作用机制，2022.1-2025.12，50万元，在研，参加

3. 安徽省自然科学基金，青年项目，2008085QH398， 靶向类风湿性关节炎的中性粒细胞膜仿生纳米递药系统的构建与研究，2020-07至2020-06,10万元，结题，主持

二、代表性研究成果和学术奖励情况

(1) Yining Niu, Tingting Gao, Hongling Ouyang, Yunxiao Zhang, Tao Gong, Zhirong Zhang, Xi Cao*，Yao Fu*，Chondroitin Sulfate-Derived Micelles for Adipose Tissue-Targeted Delivery of Celastrol and Phenformin to Enhance Obesity Treatment. ACS Applied Bio Materials 2024;7(2):1271-1289.

(2) Yi Pan, Yunxiao Zhang, Hongling Ouyang, Tao Gong, Zhirong Zhang, Xi Cao*，Yao Fu* Targeted Delivery of Celastrol via Chondroitin Sulfate Derived Hybrid Micelles for Alleviating Symptoms in Nonalcoholic Fatty Liver Disease. ACS Applied Bio Materials. Nov 20 2023;6(11):4877-4893.

(3) Yujie Wang· Fang Zhao· Xiangyu Wang· Haojie Zuo· Yiming Ru· Xi Cao*· Yang Wang*. Targeted liposomes for macrophages‑mediated pulmonary fibrosis therapy. Drug Delivery Translation Research (2024).

(4) Tingfei Tan#, Qi Huang#, Weiwei Chu, Bo Li, Jingjing Wu, Quan Xia*, Xi Cao*. Delivery of germacrone (GER) using macrophages- targeted polymeric nanoparticles and its application in rheumatoid arthritis. Drug Delivery, 2022, 29(1), 692-701.

(5) Xu Zhou*, Dandan Huang, Runkong Wang, Mingquan Wu, Liyang Zhu, Wei Peng, He Tu, Xuangeng Deng, He Zhu, Zhong Zhang, Xinming Wang, Xi Cao*. Targeted therapy of rheumatoid arthritis via macrophage repolarization. Drug Delivery. 2021,28(1);2447-2459.

(6) Xi Cao, Tingfei Tan, Dongchun Zhu, Haixia Yu, Yaru Liu, Haiyun Zhou, Yong Jin, Quan Xia. Paclitaxel-Loaded Macrophage Membrane Camouflaged Albumin Nanoparticles for Targeted Cancer Therapy. International Journal of Nanomedicine. 2020, 15(1): 1915-1928.

(7) Xi Cao, Ying Hu, Shi Luo, Yuejing Wang, Tao Gong, Xun Sun, Yao Fu, Zhirong Zhang. Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma . Acta Pharmaceutica Sinica B. 2019, 9(3):455-658.

(8) Xi Cao#, Xu Zhou#, Yu Wang, Tao Gong, Zhirong Zhang, Renhe Liu, Yao Fu. Diblock-and triblock-copolymer based mixed micelles with high tumor penetration in vitro and in vivo. Journal of Materials Chemistry B, 2016, 4(19): 3216-3224.

三、联系方式

Email：ayfyxixi@163.com