一、 个人简历
【教育背景】
2013/09-2016/06，中山大学，药学院生药学专业，博士
2010/09-2013/06，第二军医大学，药学院生药学专业，硕士
2000/09-2004/06，安徽中医学院，药学系药学专业，本科
【工作经历】
2022/01-至今，上海中医药大学附属岳阳中西医结合医院，药学研究室，副主任药师
2016/07-2021/12，上海中医药大学附属第七人民医院，中心实验室副主任，副主任药师
2007/07-2010/08，中国科学院上海药物研究所，研究实习员
2004/07-2007/06，合肥医工医药有限公司，天然药物部，实验员
二、 教学科研情况（包括主要在研课题、获奖成果等）
1.主持的科研课题：
(1) 国家自然科学基金委员会, 面上项目, 82474047, 基于靶点钩钓及多组学技术探究中药狼毒大环二萜类药效物质靶向银屑病作用机制研究，2025-01-01至2028-12-31，49万元, 在研, 主持
(2) 上海市科学技术委员会, “科技创新行动计划”国内合作项目, 23015821100, 基于“血虚风燥”理论结合靶点“钩钓”技术系统挖掘云南省民族药治疗特应性皮炎的天然成分, 2023-10 至 2025-09, 50万元, 主持
(3) 上海市卫生健康委员会，202340074, 六味润肤油摩方提取物预防特应性皮炎复发的临床疗效评价研究, 202340074 2023-10至2026-09，10万元，在研，主持
(4) 云南省天然药物药理重点实验室开放研究基金项目，YKLPNP-G2403，基于靶点垂钓技术探讨天然大环二萜 wikstroelide」靶向TFRC 诱导铁死亡治疗银屑病的作用机制研究 2025-01至2025-12，2万元，在研，主持
(5) 云南省天然药物药理重点实验室开放研究基金项目，YKLPNP-G2303，基于PI3K/Akt通路抑制作用的河朔荛花中大环二萜类成分的发现、结构修饰及抗黑素瘤机制研究 2023-01至2024-12，2万元，结题
(6) 上海中医药大学, 医养结合高水平科创项目, YYKC-2021-01-156, 院内制剂芩珠凉血合剂的药效物质基础及治疗血热证银屑病药效研究, 2022-01 至 2023-12, 2万元, 结题, 主持
(7) 上海市浦东新区卫生健康委员会, 浦东新区卫生系统学科带头人培养计划, PWRd2021-10, 基于PI3K/A kt/mTOR通路抑制作用的Daphnane类中药成分抗黑色素瘤作用机制研究, 2021-10 至 2025-09, 30万元, 在研, 主持
(8) 国家自然科学基金委员会, 青年科学基金项目, 81703672, 中药芫花中Reg3A抑制剂的发现、结构修饰及构效关系研究, 2018-01-01 至 2020-12-31, 20万元, 结题, 主持
(9) 上海市科学技术委员会, “科技创新行动计划”生物医药科技支撑专项, 17401902200, 中药六类新药 宁神颗粒的临床前研究, 2017-06 至 2020-09, 70万元, 结题, 主持
(10)上海市浦东新区卫生健康委员会，成果转换项目：PW2017F-3，中药六类新药宁神颗粒的临床前研究，2017-11至2020-10，50万元，结题，主持
(11)上海市浦东新区中医药研发与创新专项，PDZYYFCX-201713，中药六类新药宁神颗粒的临床前研究，2017-02至2019-02，50万元，结题，主持
(12)上海市浦东新区卫生健康委员会, 中医药研发与创新专项, PDZY-2018-0801, 院内制剂-肾乙方颗粒的 开发, 2018-10 至 2021-09, 30万元, 结题, 主持
(13)上海市浦东新区卫生健康委员会, 优秀青年医学人才培养计划, PWRq2016-05, 中药六类新药冬柏通淋 颗粒药学研究, 2016-11 至 2019-12, 20万元, 结题，主持
2.获奖情况
1) 李福伦、邓禹、朱建勇、段彦娟、郭冬婕、郭婉军、刘欣、王怡、张明、华亮、王一飞、李苏，海派夏氏李福伦中医皮肤团队，2024年度中华中医药学会科学技术奖·华佗中医药奖。2024，奖励
2) 李福伦，邓禹，朱建勇，段彦娟，郭冬婕，郭婉军，王怡，基于海派夏氏皮肤科外治特色疗法的技术创新与应用，上海医学科技奖。二等奖，2023，奖励 2023.06
3) 李福伦，邓禹，朱建勇，段彦娟，郭冬婕，郭婉军，王怡，刘欣，华亮，基于“夏氏皮肤科外治特色疗法”中西结合关键技术创新与应用，中国中西医结合学会科学技术奖，二等奖，2022，奖励 2022.12
4) 张宏; 朱建勇; 张苗; 夏伟; 叶颖; 宋雅楠; 张莉君，疤痕止痒软化膏防治增生性瘢痕的有组分、作用机制及临床疗效, 上海市浦东新区人民政府 , 科技进步二等奖, 其他, 2017
三、 论著情况（包括代表性论文、专著、教材）
(1) Wang, Yi#; Lu, Han-Zhi#; Cheng, Lin-Yan; Guo, Wan-Jun; Hu, Yue; Du, Xin-Ran; Liu, Xin; Xu, Ming-Yuan; Liu, Ye-Qiang; Zhang, Yan-Bin; Xi, Ruo-Fan; Wang, Pei-Yao; Liu, Xin; Duan, Yan-Juan; Zhu, Jian-Yong*; Li, Fu-Lun*. Targeting mitochondrial dysfunction in atopic dermatitis with trilinolein: A triacylglycerol from the medicinal plant Cannabis fructus. Phytomedicine, 2024, 132: 155856.
(2) Hu, Yue; Pan, Rong-Rong; Wang, Yi; Ma, Ming-Hua; Peng, Ying; Fan, Wei-Qing; Zhang, Ruo-Xi; Nian, Hua*; Zhu, Jian-Yong*. Daphne genkwa: Ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. Fitoterapia, 2024, 177: 106089.
(3) Liu, Xin#; Xi, Ruo-Fan#; Cheng, Lin-Yan#; Wang, Yi; Nie, Yi-Wen; Yan, Ge; Guo, Dong-Jie; Guo, Wan-Jun; Du, Ting; Lu, Han-Zhi; Wang, Pei-Yao; Zhu, Jian-Yong*; Li, Fu-Lun*. Effectiveness and mechanism of the Chinese medicine Weiren Xiaoyou formula in improving palmoplantar warts. Heliyon, 2024, 10(10): e31376.
(4) Liu, Xin#; Wang, Yi#; Xi, Ruo-Fan#; Guo, Dong-Jie; Guo, Wan-Jun; Cheng, Lin-Yan; Du, Ting; Lu, Han-Zhi; Wang, Pei-Yao; Duan, Yan-Juan; Zhu, Jian-Yong*; Li, Fulun*. Identification of IRF1 as a Novel Pyroptosis-Related Prognostic Biomarker of Atopic Dermatitis. Genetic Testing and Molecular Biomarkers, 2023, 27(12): 370-383.
(5) Zhang, Chun-Yan#; Xu, Shun#; Yu, Lei#; Nie, Yi-Wen; Li, Si-Bo*; Zhu, Jian-Yong*. Lathyrane diterpenoids from Euphorbia lathyris induce cell-cycle arrest and apoptosis in human hypertrophic scar cells. Natural Product Research 2023: 1-10.
(6) Zou, Jia-ling#; Duan, Yan-Juan#; Wang, Yi#; Liu, Ai-Jun; Chen,Yuan-Ran; Guo, Dong-Jie; Guo, Wan-Jun; Li Shuang; Su Zhou; Wu Yang; Lu Han-Zhi; Deng Yu*; Zhu, Jian-Yong*; Li Fu-Lun* Phellopterin cream exerts an anti-inflammatory effect that facilitates diabetes-associated cutaneous wound healing via SIRT1. Phytomedicine, 2022, 107: 154447.
(7) Wang, Guo-Kai*; Sun, Yun-Peng; Jin, Wen-Fang; Yu, Yang; Zhu, Jian-Yong*; Liu, Jin-Song*. Limonoids from Swietenia macrophylla and their antitumor activities in A375 human malignant melanoma cells. Bioorganic Chemistry, 2022, 123: 105780.
(8) Xu, Ning; Chen, Yuan-Ran; Guo, Dong-Jie; Deng, Yu; Guo, Wan-Jun; Liu, Xin; Wang, Yi; Lu, Han-Zhi; Liu, Ai-Jun; Zhu, Jian-Yong*; Li, Fu-Lun*. Rhein promotes the proliferation of keratinocytes by targeting oestrogen receptors for skin ulcer treatment. BMC Complementary Medicine and Therapies, 2022, 22(1): 209.
(9) Li, Yuan; Zhang, Chun-Yan; Nie, Yi-Wen; Zhang, Rui-Feng; Zhai, Xiao-Xiang; Duan, Yan-Juan; Fan, Wei; Gu, Wei-Ying; Shi, Kou-Rong; Luo, Lan*; Zhu, Jian-Yong*. Antitumor Activity of Ethyl Acetate Extraction of Wikstroemia chamaedaphne: Cell Cycle Arrest and Apoptosis-Inducing Activity in Melanoma Cells. Records of Natural Products, 2022, (6): 559-571.
(10)Xu, Jin-Biao*; Xie, Xiao-Yan; Zhou, Qing-Qing; Zhu, Jian-Yong*. Abieshanesides A and B; two unique ent-18;19-dinoricetexane diterpenoid glycosides from Abies beshanzuensis M.H. Wu. Fitoterapia; 2022; 156: 105096.
(11)Nie, Yi-Wen; Li, Yuan; Luo, Lan*; Zhang, Chun-Yan; Fan, Wei; Gu, Wei-Ying; Shi, Kou-Rong; Zhai, Xiao-Xiang; Zhu, Jian-Yong*. Phytochemistry and Pharmacological Activities of the Diterpenoids from the Genus Daphne. Molecules; 2021; 26(21): 6598.
(12)Yuan, Han-Tao; Li, Qun-Feng; Tian, Tian; Zhang, Chun-Yan; Huang, Zou-Qin; Fan, Chun-Xiang; Mei, Ke; Zhou, Jie; Zhai, Xiao-Xiang; Li, Si-Bo*; Zhu, Jian-Yong*. Lathyrane diterpenoids from Jatropha podagrica and their antitumor activities in human osteosarcoma cells. Natural Product Research 2021; 35(23): 5089-5095.
(13)Chen, Wei-Zhen; Wang, Guo-Kai *; Mei Ke; Zhu Jian-Yong*. Coumarins from Angelica dahurica and Their Antitumor Activities in Human MG-63 Osteosarcoma Cells. Records of Natural Products 2021; 15:356-362.
(14) Pan, Rong-Rong; Zhang, Chun-Yan; Li, Yuan; Zhang, Bing-Bing; Zhao, Liang; Ye, Ying; Song, Ya-Nan; Zhang, Miao; Tie, Hong-Yun; Zhang, Hong*; Zhu, Jian-Yong*. Daphnane Diterpenoids from Daphne genkwa Inhibit PI3K/Akt/mTOR Signaling and Induce Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells. Journal of Natural Products 2020; 83: 1238-1248.
(15)Zhang, Chun-Yan; Zhang, Li-Jun; Lu, Zhi-Cheng; Ma, Chen-Yun; Ye, Ying; Rahman, Khalid; Zhang, Hong*; Zhu, Jian-Yong*. Antitumor Activity of Diterpenoids from Jatropha gossypiifolia: Cell Cycle Arrest and Apoptosis-Inducing Activity in RKO Colon Cancer Cells. Journal of Natural Products 2018; 81:1701-1710.
(16)Zhang, Chun-Yan; Pan, Rong-Rong; Zhang, Xiao-Dan; Zhou, Ying; Ye, Ying; Xia, Jing; Rahman, Khalid; Zhang, Hong*; Zhu, Jian-Yong*. New tetracyclic triterpenoids from Jatropha gossypiifolia induce cell-cycle arrest and apoptosis in RKO cells. Fitoterapia 2018; 130: 145-151.
(17)Zhang, Chun-Yang; Luo, Lan*; Xia, Jing; Song, Ya-Nan; Zhang, Li-Jun; Zhang, Miao; Rahman, Khalid; Ye, Yin; Zhang, Hong; Zhu, Jian-Yong*. Sesquiterpenes and Lignans from the Flower Buds of Daphne genkwa and Their Nitric Oxide Inhibitory Activities. Natural Product Research 2018; 32:2893-2899.
(18) Li, Xiao-Qin; Rahman Khalid; Zhu, Jian-Yong*; Zhang Hong*. Chemical constituents and pharmacological activities of Stellera Chamaejasme. Current pharmaceutical design 2018; 24: 2825-2838.
(19) Li Xiao-Qin; Song Ya-Nan; Wang Su-Juan; Rahman Khalid; Zhu, Jian-Yong* and Hong Zhang* Saikosaponins: a review of pharmacological effects Journal of Asian natural products research 2018; 20: 399-411.
(20) Zhu, Jian-Yong#; Wang, Rui-Min#; Lou, Lan-Lan; Li Wei; Tang, Gui-Hua; Bu, Xian-Zhang*; Yin Sheng*. Jatrophane Diterpenoids as Modulators of P-Glycoprotein-Dependent Multidrug Resistance (MDR): Advances of Structure-Activity Relationships and Discovery of Promising MDR Reversal Agents. Journal of Medicinal Chemistry 2016; 59:6353-6369.
四、 主要研究方向，研究生带教情况
以活性筛选为导向从中药及中药复方中提取、分离、鉴定结构新颖的活性化合物，并进行结构修饰和相关药效物质的药理活性研究，同时从事医院院内制剂及传统中医药的新药开发和研究。
五、 联系方式：
办公室电话：021-65161782
邮箱：jyzhu82@shutcm.edu,cn
