一、个人简历
冯雪枫，女，1996年6月生，首都医科大学医学博士，副教授，中药学硕士研究生导师，现任安徽中医药大学第一附属医院（第一临床医学院）主管药师、科研秘书。主要学术兼职包括安徽省药学会中药药事管理专业委员会委员、秘书，安徽省药膳研究会委员，安徽省质谱学会委员。主要研究方向为中药防治脑血管疾病的药理研究。
二、近五年教学科研情况
（1）国家自然科学基金，青年科学基金项目，No.82404896，基于RhoAROCK2-PFN1信号轴介导小胶质细胞表型分化探究桃红四物汤促进脑缺血后髓鞘修复的作用及机制，30万元，在研，主持。
（2）安徽省自然科学基金，青年项目，No.2408085QH281, 桃红四物汤靶向NCAN/RhoA/ROCK2通路调控星形胶质细胞表型分化促脑缺血后髓鞘修复的机制研究，8万元，在研，主持。
（3）安徽中医药大学临床科研重点项目，No.2024YFYLCZX22，桃红四物汤靶向RhoA/ROCK2/PFN1信号轴调控星形胶质细胞表型分化促脑缺血大鼠髓鞘修复的机制研究，10万元，在研，主持。
（4）北京市自然科学基金，面上项目，No.7212161，基于多模态脑网络分析揭示补阳还五汤干预脑缺血大鼠远隔机能障碍的神经调控模式，20万元，结题, 参与。
三、代表性学术论文
[1] Feng Xuefeng, Lei Jianfeng, Li Manzhong, Zhan Yu, Yang Le, Lu Yun, Li Mingcong, Zhuang Yuming, Wang Lei, Zhao Hui. Magnetic Resonance Imaging Investigation of Neuroplasticity After Ischemic Stroke in Tetramethylpyrazine-Treated Rats. Frontiers in Pharmacology. 2022, 13:851746.
[2] Feng Xuefeng, Li Mingcong, Lin Ziyue, Li Manzhong, Lu Yun, Zhuang Yuming, Lei Jianfeng, Wang Lei, Zhao Hui. Tetramethylpyrazine promotes stroke recovery by inducing the restoration of neurovascular unit and transformation of A1/A2 reactive astrocytes. Frontiers in Cellular Neuroscience, 2023, 17:1125412.
[3] Feng Xuefeng, Li Mingcong, Lin Ziyue, Lu Yun, Zhuang, Yuming, Lei Jianfeng, Liu Xiaonan, Zhao Hui. Tetramethylpyrazine promotes axonal remodeling and modulates microglial polarization via JAK2-STAT1/3 and GSK3-NFκB pathways in ischemic stroke. Neurochemistry international. 2023 Aug 30;170.
[4] 冯雪枫, 李慢中, 詹宇, 杨乐, 陆允, 李明聪, 赵晖. 补阳还五汤促进脑缺血大鼠脑组织微结构重塑的作用. 北京中医药大学学报.2021,44(06):500-509.
[5] Tang Linfeng, Wang Dandan, Chang Hao, Liu Zhuqing, Zhang Xueting, Feng Xuefeng, Han Lan. Treating ischemic stroke by improving vascular structure and promoting angiogenesis using Taohong Siwu Decoction: An integrative pharmacology strategy. Journal of Ethnopharmacology. 2024 Oct 5;332:118372.
[6] Yang Le, Li Manzhong, Zhan Yu, Feng Xuefeng, Lu Yun, Li Mingcong, Zhuang Yuming, Lei Jianfeng, Zhao Hui. The Impact of Ischemic Stroke on Gray and White Matter Injury Correlated With Motor and Cognitive Impairments in Permanent MCAO Rats: A Multimodal MRI-Based Study. Frontiers in Neurology. 2022, 13:834329.
[7] Yang Le, Lei Jianfeng, Ouyang Junyao, Li Manzhong, Zhan Yu, Feng Xuefeng, Lu Yun, Li Mingcong, Wang Lei, Zou Haiyan, Zhao Hui. Effect of Neurorepair for Motor Functional Recovery Enhanced by Total Saponins From Trillium tschonoskii Maxim. Treatment in a Rat Model of Focal Ischemia. Frontiers in Pharmacology. 2021, 12:763181.
[8] Yang Le, Li Changyi, Ouyang Junyao, Li Manzhong, Zhan Yu, Feng Xuefeng, Lu Yun, Li Mingcong, Lei Jianfeng, Zhao Ting, Wang Lei, Zou Haiyan, Zhao Hui. Trillium tschonoskii rhizomes' saponins induces oligodendrogenesis and axonal reorganization for ischemic stroke recovery in rats. Journal of Ethnopharmacology. 2021, 279:114358.
[9] Zhan Yu, Li Manzhong, Yang Le, Feng Xuefeng, Lei Jianfeng, Zhang Nan, Zhao Yuanyuan, Zhao Hui. The three-phase enriched environment paradigm promotes neurovascular restorative and prevents learning impairment after ischemic stroke in rats. Neurobiol Dis 2020, 146:105091.
[10] Zhan Yu, Li Manzhong, Yang Le, Feng Xuefeng, Zhang Qiuxia, Zhang Nan, Zhao Yuanyuan, Zhao Hui. An MRI study of neurovascular restorative after combination treatment with Xiaoshuan Enteric-coated capsule and enriched environment in rats after stroke. Frontiers in Neuroscience, 2019, 13:701.
[11] Li Manzhong; Zhao Yuming; Zhan Yu; Yang Le; Feng Xuefeng; Lu Yun; Lei Jianfeng; Zhao Ting; Wang Lei; Zhao Hui, Enhanced white matter reorganization and activated brain glucose metabolism by enriched environment following ischemic stroke: micro PET/CT and MRI study. Neuropharmacology, 2020, 176: 108202.
[12] Li Manzhong; Zhan Yu; Yang Le; Feng Xuefeng; Zou Haiyan; Lei Jianfeng; Zhao Ting; Wang Lei; Zhao Hui. MRI evaluation of axonal remodeling after combination treatment with Xiaoshuan Enteric-coated capsule and enriched environment in rats after ischemic stroke. Frontiers in Physiology, 2019, 10:1528.
[13] 张琪, 李慢中, 冯雪枫, 李明聪, 赵晖. 补阳还五汤对脑缺血大鼠梗死灶周围脑区新生神经细胞增殖、分化及Wnt/β-catenin信号通路的影响[J]. 北京中医药大学学报, 2021,44(11):1002-1010.
[14] 李明聪, 赵婷, 赵晖, 冯雪枫, 陆允, 杨乐, 詹宇, 高利. 痰火方改善脑缺血大鼠脑灌注及保护神经胶质细胞的作用[J]. 北京中医药大学学报, 2021,44(07):605-614.
[15] 庄雨明, 杨乐, 欧阳俊摇, 邹海艳, 冯雪枫, 陆允, 李明聪, 赵晖. 延龄草皂苷对脑缺血大鼠梗死灶周围皮层少突胶质细胞GSK-3/β-catenin/CRMP2信号表达的影响[J]. 中国中医药信息杂志, 2023,30(10):108-115.
四、主要研究方向
针对缺血性脑卒中开展中药防治脑血管疾病的药理作用及机制研究，以改善中枢微环境、提高神经可塑性等环节为重点，致力于探索明确脑卒中的病理进程、治疗靶标和关键分子机制，开展中医药防治脑病的基础与临床应用研究。
五、联系方式
邮箱：13865519361@163.com
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