一、个人简历
周婷婷，博士，上海市药物（中药）代谢产物研究重点实验室主任；海军军医大学药学院药物分析学教研室主任、教授、博士生导师；国家青年岐黄学者，上海市卫生健康委优秀学科带头人，上海市东方英才，上海市优秀青年教师。长期从事中药药效物质与代谢研究。主持包括6项国家自然科学基金在内的10余项省部级以上科研及人才项目；以第一/通讯作者在Psychiatry Clin Neurosci、Med Res Rev、Phytomedicine、Food Chem、Biomed Pharmacother等国际权威学术刊物上发表SCI论文49篇，其中IF>10分8篇，IF>5分22篇，研究成果获得国际广泛认可，总引用次数2000余次。单篇最高他引>1000次，被web of science纳入molecular biology& genetics学术领域最优秀的前1%之列。申请国家发明专利23项，11项获授权，第一完成人获上海市药学科技奖二等奖。应邀担任iMeta（IF=33.2）、Acta Pharm Sin B（IF=14.6）、J Pharm Anal（IF=8.9）杂志青年编委；Front Pharmacol（IF=4.8）、Front Chem（IF=4.2）、Pharmaceuticals（IF=4.8）客座主编等；《药物分析杂志》、《沈阳药科大学学报》、《中草药》、《世界科学技术-中医药现代化杂志》等杂志编委。主编、副主编高等教育出版社、人民卫生出版社等国家级规划教材9部；同时担任中国药学会药物分析专业委员会副主任委员，世界中医药学会联合会中药系统科学与工程分会常务理事，上海市药学会理事会常务理事，上海市药学会药物分析专业委员会主任委员。
二、教学科研情况（包括主要在研课题、获奖成果等）
1. 国家中医药管理局中医药特色人才培养工程（岐黄工程）重点项目，国中医药人教函[2022]256号，青年岐黄学者培养项目，2023.01-2025.12，30万，在研，主持
2. 国家自然科学基金面上项目，82474056，淡豆豉调控肠-肝轴重编程尿素循环逆转京尼平致肝脏/肠黏膜损伤作用的分子机制研究，2025.01-2028.12，48万，在研，主持
3. 国家自然科学基金国际和地区合作项目（内地-澳门），82461160264，栀子豉汤通过调控肠-肝/脑轴氨基酸代谢靶向Keap1/Nrf2通路监督增效的配伍机制研究，2025.01-2027.12，170万，在研，主持
4. 科技部科创2030项目中医药防治蒽环类药物相关心脏损伤干预方案与机制研究，2023ZD0502605，课题5:中药复方防治ACT的作用机制研究子课题，2024.08-2028.07，330万，在研，主持
5. 上海市卫生健康委员会卫生健康学科带头人计划，2022XD037，肠道菌群调控的栀子豉汤配伍减毒增效作用机制研究，2022.07-2025.06，45万，在研，主持
6. 上海市药学科技奖二等奖，第一完成人。
7. 上海市优秀教学成果一等奖，第一完成人。
8. 上海市一流本科课程《药物分析》，课程负责人。
9. 海军优秀课程《药物分析》，课程负责人。
10. 全国高等学校药学类专业青年教师教学能力大赛一等奖，第一完成人。
11. 全国高等学校药学类专业青年教师微课教学大赛一等奖，第一完成人。
三、论著情况（包括代表性论文、专著、教材）
1.发表论文
(1) Xiaojing Liu#, Jing He#, Lixun Cui#, Ying Ye, Miaomiao Luo,Hongzhan Xu, Yujia Zhai, Zixin Zhao, Taohong Huang, Yunxia Li, Jian-lin Wu, Jun Wen, Yong Wang, Tingting Zhou*.Limosilactobacillus reuteri-butyrate axis in depression therapy: A key pathway discovered through a novel preclinical human flora-associated animal model.Pharmacologlcal Research. 2025;220:107941.(2024Impact factor:10.5)
(2) Wen Yang#, Wen Zhang#, Xinhui Huang#, Shuwen Geng, Yujia Zhai, Yuetong Jiang, Tian Tian, Yuye Gao, Jing He, Taohong Huang, Yunxia Li, Wenjing Zhang, Jun Wen, Jian-lin Wu*, Guangji Wang*, Tingting Zhou*. Gut Microbiota, a Potential Mediated Target for Reducing Geniposide Hepatotoxicity by Interacting with Isoflavones. Engineering. 2025, 47:222-235.（2024Impact factor: 11.6）
(3) Jing He#, Zixin Zhao#, Ying Ye, Yujia Zhai, Dexun Yu, Fangyuan Gao, Jian-Lin Wu, Jun Wen*, Tingting Zhou*. Microbiota basis of the antidepressant effects of Zhi-zi-chi Decoction: Lactobacillus rhamnosus and gut microbiota metabolism. Chinese Herbal Medicines, 2025, 17:798-807. (2024Impact factor: 8.9)
(4) Yuqi Fu, Jin Zhang,Rui Qin,Yueting Ren, Tingting Zhou*,Bo Han*, Bo Liu* .Activating autophagy to eliminate toxic protein aggregates with small molecules in neurodegenerative diseases. Pharmacol Rev. 2025 , 77:100053.（2024Impact factor: 17.3）
(5) Tingting Zhou#. Unveiling secrets of traditional Chinese medicine: Cutting-edge techniques in component analysis.Chinese Herbal Medicines. 2025,17:484-487.（2024Impact factor: 8.9）
(6) Xuan Wang#, Tian Tian#, Na Li, Lingling Zheng, Yuyao Wu, Wei Bian, Jian-Lin Wu*, Tingting Zhou*. Characterization and gelling properties of pectin extracted from Gardenia fruit. Food Hydrocolloids. 2025, 163:111055.（2024Impact factor: 12.4）
(7) Yuye Gao#, Tian Tian#, Xiaojing Liu#, Yi Zhang, Ping Hai, Wei Zhang, Yujia Zhai, Chen Wang, Jian-lin Wu*, Jun Wen*, Tingting Zhou*. Spatial metabolomics and feature-based molecular networking to unveiling in-situ quality markers landscape and reflecting geographic origins of pomegranate seeds. Food Chemistry. 2025, 471:142761.（2024Impact factor: 9.8）
(8) Yin Wang#,# ,Yuling Huang# , Guohua Wang , Ting Jiang , Shuwen Geng，Hongzhan Xu , Tingting Zhou*,Wenjing Zhang*.Time-specific study on the efficacy of stems and leaves of Arachis hypogaea L. targeting glycine/serine metabolism for insomnia treatment. Journal of Pharmaceutical Analysis，Available online 1 April 2025, 101288. doi: 10.1016/j.jpha.2025.101288.（2024Impact factor: 8.9）
(9) Wei Wang, Cheng Qian, Ting Wang, Yuetong Jiang, Yiran Zhou, Kaiyu Liu, Zhiyang Ma, Pengyi Liu, Yichi Wu, Leying Chen, Huaizhi Wang, Tingting Zhou*. A combination of faecal and intratumour microbial community profiling reveals novel diagnostic and prognostic biomarkers for pancreatic tumours. Clinical and Translational Medicine. 2024,14(6):e1726. (2024Impact factor:6.8)
(10) Yuye Gao, Tingting Zhou*. Acupuncture: A beacon of hope for primary insomnia. Sleep Medicine Reviews. 2024, 74: 101911. (2024Impact factor:9.7)
(11) Yuye Gao, Tingting Zhou*. Depressive disorder prevention by DIET crosslink: Diet, intestinal microbiota, enzyme and traits of metabolism. Trends In Food Science & Technology. 2024, 150: 104596. (2024Impact factor:15.4)
(12) Jinyi Wang, Tingting Zhou*. Unveiling gut microbiota's role: Bidirectional regulation of drug transport for improved safety Medicinal Research Reviews. 2025,45(1):311-343.(2024Impact factor:11.6)
(13) Xiqing Bian#, Na Zhou#, Yiran Zhao#, Yichao Fang, Na Li, Xin Zhang, Xuan Wang, Yunxia Li, Jian-Lin Wu*, Tingting Zhou*. Identification of Proline, 1-pyrroline-5-carboxylate, and glutamic acid as biomarkers of depression reflecting brain metabolism using carboxylomics, a new metabolomics method. Psychiatry and Clinical Neurosciences, 2022, doi: 10.1111/pcn.13517. (2022Impact factor:11.9)
(14) Yusha Luo, Tingting Zhou*. Connecting the dots: targeting the microbiome in drug toxicity. Medicinal Research Reviews. 2022,42:83-111. (2022Impact factor:13.3)
(15) Wen Miao#, Xiaojing Liu#, Na Li, Xiqing Bian, Yiran Zhao, Jing He, Tingting Zhou*, Jian-Lin Wu*. Polarity-extended composition profiling via LC-MS-based metabolomics approaches: A key to functional investigation of Citrus aurantium L. Food Chemistry, 2023,405: 134988. (2023Impact factor:8.5)
(16) Yuye Gao#, Yu Fu, Na Li, Yuetong Jiang, Xiaojing Liu, Congcong Gao, Lishuang Wang, Jian-Lin Wu*, Tingting Zhou*. Carboxyl-containing Components Delineation via Feature-based Molecular Networking: A Key to Processing Conditions of Fermented Soybean. Food Chemistry, 2023: 136321. (2023Impact factor:8.5)
(17) Jialin Liu#, Yichao Fang#, Lixun Cui#, Zhongzhao Wang, Yusha Luo, Congcong Gao, Wen Ge, Taohong Huang, Jun Wen, Tingting Zhou*. Butyrate emerges as a crucial effector of Zhi-Zi-Chi decoctions to ameliorate depression via multiple pathways of brain-gut axis. Biomedicine & Pharmacotherapy. 2022, 149:112861. (2022Impact factor:7.5)
(18) Yusha Luo#, Xingjie Zhang#, Wen Zhang#, Qiliang Yang, Wei You, Jun Wen*, Tingting Zhou*. Compatibility with Semen Sojae Praeparatum attenuates hepatotoxicity of Gardeniae Fructus by regulating the microbiota, promoting butyrate production and activating antioxidant response. Phytomedicine.2021,90:153656. (2021Impact factor:6.656)
(19) Fang-Yuan Gao#, Hai-Yan Chen#, Yu-Sha Luo#, Ji-Kuai Chen, Lang Yan, Jiang-Bo Zhu*, Guo-Rong Fan*, Ting-Ting Zhou*. “Q-markers targeted screening” strategy for comprehensive qualitative and quantitative analysis in fingerprints of Angelica dahurica with chemometric methods. Food Chemistry: X. 2021,12:100162. (2021Impact factor:6.443)
(20) Fang-Yuan Gao#, Xue-Feng Chen#, Li-Xun Cui#, Yu-Jia Zhai, Jia-Lin Liu, Cong-Cong Gao, Yi-Chao Fang, Tao-Hong Huang, Jun Wen*, Ting-Ting Zhou*. Gut microbiota mediates the pharmacokinetics of Zhi-zi-chi decoction for the personalized treatment of depression, Journal of Ethnopharmacology. 2023,302: 115934. (2023Impact factor:4.8)
(21) Yin Zhang#, Yichao Fang#, Lixun Cui#, Yuetong Jiang, Yusha Luo, Wen Zhang, Dexun Yu, Jun Wen*, Tingting Zhou*. Zhi-zi-chi decoction reverses depressive behaviors in CUMS rats by reducing oxidative stress injury via regulating GSH/GSSG pathway. Frontiers in Pharmacology. 2022,13: 887890. (2022Impact factor:5.6)
(22) Yusha Luo#, Fangyuan Gao#, Ruirui Chang#, Xingjie Zhang, Jie Zhong, Jun Wen*, Jianlin Wu*, Tingting Zhou*. Metabolomics Based Comprehensive Investigation of Gardeniae Fructus Induced Hepatotoxicity. Food and Chemical Toxicology. 2021, 153:112250. (2021Impact factor:5.572)
(23) Yin Zhang#, Yusha Luo#, Dongqi Zhang, Bo Pang, Jun Wen*, Tingting Zhou*. Predicting a Potential Link to Antidepressant Effect: Neuroprotection of Zhi-zi-chi Decoction on Glutamate-induced Cytotoxicity in PC12 Cells. Frontiers in Pharmacology. 2021, 11:625108. (2021Impact factor:5.988)
(24) Hui Guo#, Xiaojing Liu#, Yuetong Jiang#, Jing He, Wen Ge, Hongyuan Hao, Taohong Huang, Ying He*, Jun Wen*, Tingting Zhou*. Characterization and quantification of the Chinese medical formula Zhi-Zi-Chi decoction, a systematic strategy for the attenuation and synergy of compatibility mechanism. Journal of Pharmaceutical and Biomedical Analysis, 2023, 223: 115130. (2023Impact factor:3.1)
(25) Yichao Fang, Tingting Zhou*. Editorial: Antidepressant mechanisms of natural products based on multi-omics technologies. Frontiers in Pharmacology, 2023,14:1135791. (2023Impact factor: 4.4).
(26) Ruirui Chang#, Jialin Liu#, Yusha Luo#, Taohong Huang, Qiang Li, Jun Wen*, Weidong Chen*, Tingting Zhou*. Isoflavones' effects on pharmacokinetic profiles of main iridoids from Gardeniae Fructus in rats. Journal of Pharmaceutical Analysis. 2020, 10:571-580. (2020Impact factor:4.769)
2.编写教材
(1) 高等教育出版社《分析化学》，2024，主编
(2) 高等教育出版社《药物分析实验指导》，2025，主编
(3) 人民卫生出版社《中国医学教育题库（药学专业题库）》（第2版），2024，副主编
(4) 人民卫生出版社《中国医学教育题库（药学专业题库）》，2019，副主编
(5) 人民卫生电子音像出版社《药物分析实验操作规范与安全技能教程》，2023，副主编
(6) 中国医药科技出版社《中药质量分析与评价》，2024，编委
(7) 人民卫生出版社《药物分析（第2版）》，2024，编委
(8) 中国医药科技出版社《中药分析学（第3版）》2023，编委
(9) 科学出版社《基础药物分析》，2023，编委
(10) 科学出版社《中药分析学》，2022，编委
(11) 中国中医药出版社《中药分析学》，2021，编委
(12) 中国医药科技出版社《药物分析（第4版）》2019，编委
(13) 清华大学出版社《药物分析学（第2版）》2018，编委
(14) 中国医药科技出版社《药物分析（第3版）》2017，编委
(15) 北京科学技术出版社《中药药物代谢动力学》2017，编委
四、主要研究方向，研究生带教情况
1.主要研究方向
药物质量控制、体内代谢及中药药效物质研究；肠道菌群介导的药物（天然产物）药效作用机制研究
2.研究生带教情况
指导研究生获岛津杯全国药物分析优秀论文评选交流会优秀论文二等奖2项，第二届药学研究生学术研讨会三等奖1项，药学研究生学术研讨会暨药学研究生国际学术会议1项，上海市药学会青年论文报告会特等奖、一等奖、二等奖40余项；指导研究生发表SCI研究论文30余篇和中文核心期刊论10余篇；指导2020级硕士研究生高葱葱获安徽中医药大学优秀硕士学位论文。
五、联系方式：办公电话（系统安全问题，不要留手机号）、邮箱
办公电话：021-81871262
邮箱：tingting_zoo@163.com
